Induction of apoptosis in DLD-1 human colon cancer cells by peridinin isolated from the dinoflagellate, Heterocapsa triquetra

Tatsuya Sugawara; Kyoko Yamashita; Shota Sakai; Akira Asai; Akihiko Nagao; Tomotaka Shiraishi; Ichiro Imai; Takashi Hirata

doi:10.1271/bbb.60597

Induction of apoptosis in DLD-1 human colon cancer cells by peridinin isolated from the dinoflagellate, Heterocapsa triquetra

Tatsuya Sugawara, Kyoko Yamashita, Shota Sakai, Akira Asai, Akihiko Nagao, Tomotaka Shiraishi, Ichiro Imai, Takashi Hirata

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Peridinin, which is uniquely present in dinoflagellates, is one of the most abundant carotenoids found in nature. We evaluated the apoptotic effect of peridinin on DLD-1 human colorectal cancer cells. Peridinin significantly reduced the cell viability in a dose-dependent manner (0-20 μM) and induced apoptosis by activating both caspase-8 and caspase-9. Our findings could be important for the high-performance utilization of marine bioproducts.

Original language	English
Pages (from-to)	1069-1072
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	71
Issue number	4
DOIs	https://doi.org/10.1271/bbb.60597
Publication status	Published - 2007
Externally published	Yes

Keywords

Apoptosis
Carotenoids
Colon cancer cells
Dinoflagellate
Peridinin

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1271/bbb.60597

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Induction of apoptosis in DLD-1 human colon cancer cells by peridinin isolated from the dinoflagellate, Heterocapsa triquetra. / Sugawara, Tatsuya; Yamashita, Kyoko; Sakai, Shota; Asai, Akira; Nagao, Akihiko; Shiraishi, Tomotaka; Imai, Ichiro; Hirata, Takashi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 71, No. 4, 2007, p. 1069-1072.

Research output: Contribution to journal › Article › peer-review

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AU - Sugawara, Tatsuya

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AU - Sakai, Shota

AU - Asai, Akira

AU - Nagao, Akihiko

AU - Shiraishi, Tomotaka

AU - Imai, Ichiro

AU - Hirata, Takashi

PY - 2007

Y1 - 2007

N2 - Peridinin, which is uniquely present in dinoflagellates, is one of the most abundant carotenoids found in nature. We evaluated the apoptotic effect of peridinin on DLD-1 human colorectal cancer cells. Peridinin significantly reduced the cell viability in a dose-dependent manner (0-20 μM) and induced apoptosis by activating both caspase-8 and caspase-9. Our findings could be important for the high-performance utilization of marine bioproducts.

AB - Peridinin, which is uniquely present in dinoflagellates, is one of the most abundant carotenoids found in nature. We evaluated the apoptotic effect of peridinin on DLD-1 human colorectal cancer cells. Peridinin significantly reduced the cell viability in a dose-dependent manner (0-20 μM) and induced apoptosis by activating both caspase-8 and caspase-9. Our findings could be important for the high-performance utilization of marine bioproducts.

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KW - Carotenoids

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KW - Dinoflagellate

KW - Peridinin

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Induction of apoptosis in DLD-1 human colon cancer cells by peridinin isolated from the dinoflagellate, Heterocapsa triquetra

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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