Abstract
Peridinin, which is uniquely present in dinoflagellates, is one of the most abundant carotenoids found in nature. We evaluated the apoptotic effect of peridinin on DLD-1 human colorectal cancer cells. Peridinin significantly reduced the cell viability in a dose-dependent manner (0-20 μM) and induced apoptosis by activating both caspase-8 and caspase-9. Our findings could be important for the high-performance utilization of marine bioproducts.
Original language | English |
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Pages (from-to) | 1069-1072 |
Number of pages | 4 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 71 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2007 |
Externally published | Yes |
Keywords
- Apoptosis
- Carotenoids
- Colon cancer cells
- Dinoflagellate
- Peridinin
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry