Induction of apoptosis in DLD-1 human colon cancer cells by peridinin isolated from the dinoflagellate, Heterocapsa triquetra

Tatsuya Sugawara, Kyoko Yamashita, Shota Sakai, Akira Asai, Akihiko Nagao, Tomotaka Shiraishi, Ichiro Imai, Takashi Hirata

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Peridinin, which is uniquely present in dinoflagellates, is one of the most abundant carotenoids found in nature. We evaluated the apoptotic effect of peridinin on DLD-1 human colorectal cancer cells. Peridinin significantly reduced the cell viability in a dose-dependent manner (0-20 μM) and induced apoptosis by activating both caspase-8 and caspase-9. Our findings could be important for the high-performance utilization of marine bioproducts.

Original languageEnglish
Pages (from-to)1069-1072
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume71
Issue number4
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Apoptosis
  • Carotenoids
  • Colon cancer cells
  • Dinoflagellate
  • Peridinin

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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