Inducible repression of CREB function disrupts amygdala-dependent memory

S. A. Josselyn, S. Kida, A. J. Silva

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Evidence from Aplysia, Drosophila, mice, and rats indicates that the CREB (cAMP/Ca 2+ responsive element binding protein) family of transcription factors is critical for long-term memory. Recent findings, however, suggest that performance abnormalities may contribute to the memory deficits attributed to CREB manipulations in mammals. To clarify the role of CREB in memory, we used a paradigm, conditioned taste avoidance, that places few performance demands on the subject. We show that lesioning or blocking protein synthesis in the basolateral amygdala of mice disrupts conditioned taste aversion. Furthermore, either chronically or acutely disrupting CREB function in two different types of genetically modified mice blocks memory for conditioned taste aversion measured 24h following training. Together, these findings indicate that CREB-mediated transcription and protein synthesis are required for conditioned taste aversion memory.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalNeurobiology of Learning and Memory
Volume82
Issue number2
DOIs
Publication statusPublished - 2004 Sep 1

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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