Abstract
Synthetic oligonucleotides (ONs) are valuable tools that interfere with gene expression by specifically binding to target genes in a sequence-specific manner. Reactive ONs containing cross-linking agents are expected to induce efficient inhibition because they bind covalently to target genes. In recent years, researchers have reported several cross-linking reactions that target DNA induced by external stimuli. This short review highlights recently developed novel cross-linking reactions, focusing particularly on nucleoside derivatives developed by our group.
Original language | English |
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Pages (from-to) | 2579-2585 |
Number of pages | 7 |
Journal | Organic and Biomolecular Chemistry |
Volume | 9 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2011 Apr 21 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry