Induced cross-linking reactions to target genes using modified oligonucleotides

Fumi Nagatsugi, Shuhei Imoto

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Synthetic oligonucleotides (ONs) are valuable tools that interfere with gene expression by specifically binding to target genes in a sequence-specific manner. Reactive ONs containing cross-linking agents are expected to induce efficient inhibition because they bind covalently to target genes. In recent years, researchers have reported several cross-linking reactions that target DNA induced by external stimuli. This short review highlights recently developed novel cross-linking reactions, focusing particularly on nucleoside derivatives developed by our group.

Original languageEnglish
Pages (from-to)2579-2585
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number8
DOIs
Publication statusPublished - 2011 Apr 21

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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