Indomethacin Inhibits the Antihypertensive Effect of Captopril, SQ 14225, in Low Renin Hypertension

Keishi Abe, Toru Itoh, Yutaka Imai, Makito Sato, Toshikazu Goto, Yoichi Otsuka, Kaoru Yoshinaga

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The antihypertensive mechanism of orally active angiotensin I-converting enzyme inhibitor, SQ 14225 (SQ), in low renin hypertension was investigated. In the SQ-responder with low renin hypertension, the hypotensive effect of SQ was abolished after the inhibition of endogenous prostaglandin (PG) synthesis with indomethacin, while no significant change in blood pressure was found in the SQ-responder with normal renin hypertension. These results suggest that SQ may potentiate the vasodilating PG system, contributing to the antihypertensive mechanism in SQ responders with low renin hypertension.

Original languageEnglish
Pages (from-to)117-118
Number of pages2
Journalthe tohoku journal of experimental medicine
Volume132
Issue number1
DOIs
Publication statusPublished - 1980

Keywords

  • antihypertensive mechanism
  • captopril
  • converting enzyme inhibitor
  • low renin hypertension
  • prostaglandin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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