Indenol ether formation from aryl alkynes bearing ortho-acetals: An unprecedented rearrangement in palladium-catalyzed carboalkoxylation

Itaru Nakamura, Gan B. Bajracharya, Yuya Mizushima, Yoshinori Yamamoto

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

Activated ethers: The shown reaction of the dialkylacetals 1 gave the carboalkoxylation products 2 in high to moderate yields. Mechanistic investigation revealed that the reaction proceeded through the addition of an acetal C-O bond to the C-C triple bond, followed by an unprecedented rearrangement of an alkynyl group substituent.

Original languageEnglish
Pages (from-to)4328-4331
Number of pages4
JournalAngewandte Chemie - International Edition
Volume41
Issue number22
DOIs
Publication statusPublished - 2002 Nov 15

Keywords

  • Acetals
  • Alkynes
  • Palladium
  • Rearrangement
  • Synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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