Increases of neuropeptide Y-like immunoreactivity in plasma during insulin-induced hypoglycemia in man

Kazuhiro Takahashi, Toraichi Mouri, Osamu Murakami, Keiichi Itoi, Masahiko Sone, Makoto Ohneda, Mitsuru Nozuki, Kaoru Yoshinaga

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Neuropeptide Y-like immunoreactivity (NPY-LI) in plasma during insulin-induced hypoglycemia was measured in 4 healthy male volunteers. Plasma NPY-LI increased from 167±11 pg/ml to 247±25 pg/ml 30 min after the administration of insulin (0.1 U/kg body weight IV), reached the maximum (296±6 pg/ml) 45 min after the insulin, and then decreased. These results suggest that NPY is released into the systemic circulation during insulin-induced hypoglycemia in man.

Original languageEnglish
Pages (from-to)433-435
Number of pages3
JournalPeptides
Volume9
Issue number2
DOIs
Publication statusPublished - 1988

Keywords

  • Insulin-induced hypoglycemia
  • Neuropeptide Y
  • Neuropeptide Y-like immunoreactivity
  • Radioimmunoassay

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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