Neuropeptide Y-like immunoreactivity (NPY-LI) in plasma during insulin-induced hypoglycemia was measured in 4 healthy male volunteers. Plasma NPY-LI increased from 167±11 pg/ml to 247±25 pg/ml 30 min after the administration of insulin (0.1 U/kg body weight IV), reached the maximum (296±6 pg/ml) 45 min after the insulin, and then decreased. These results suggest that NPY is released into the systemic circulation during insulin-induced hypoglycemia in man.
- Insulin-induced hypoglycemia
- Neuropeptide Y
- Neuropeptide Y-like immunoreactivity
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience