Increased urinary leukotriene E4 excretion in patients with atopic dermatitis

T. Hishinuma, N. Suzuki, S. Aiba, H. Tagami, M. Mizugaki

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Background: Synthesis of cysteinyl leukotrienes (LTs) is known to play a part in the pathogenesis of inflammatory diseases. Objectives: To define the involvement of cysteinyl LTs in atopic dermatitis (AD). Methods Synthesis of cysteinyl LTs was assessed in patients with AD and healthy volunteers by measuring urinary LTE4, a useful index of systemic cysteinyl LT synthesis, using liquid chromatography/tandem mass spectrometry. Results: Mean ± SD urinary LTE4 levels in patients with AD (125 ± 69 pg mg-1 creatinine, n = 20) were significantly higher (P < 0.01) than in healthy volunteers (60 ± 19 pg mg-1 creatinine, n = 17). A significant correlation between urinary LTE4 and total serum IgE levels in patients with AD was observed (r = 0.643, P < 0.05). Conclusions: Our findings demonstrate an enhanced synthesis of cysteinyl LTs in patients with AD and suggest that cysteinyl LTs are involved in the pathophysiology of AD.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalBritish Journal of Dermatology
Issue number1
Publication statusPublished - 2001


  • Atopic dermatitis
  • IgE
  • Leukotriene E
  • Liquid chromatography
  • Tandem mass spectrometry

ASJC Scopus subject areas

  • Dermatology


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