Increased tumor tissue pressure in association with the growth of rat tumors

Katsuyoshi Hori, Maroh Suzuki, Ikuo Abe, Sachiko Saito

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

In order to elucidate further the mechanisms of central necrosis formation and drug delivery into tumor tissue, the interstitial fluid pressure in the normal subcutis and in rat ascites hepatoma AH109A and AH272 tumors was measured by means of a modified diffusion chamber technique. Using our apparatus for determining tissue pressures, we can obtain an exact zero reference-point and thus analyze daily changes in tumor interstitial fluid pressure. Tumor interstitial fluid pressure was found to be always positive and significantly higher than that in the normal subcutis, which was negative (P<0.001). The pressure increased with tumor growth. Highly significant correlations between the tumor size and the tumor interstitial fluid pressure were observed in both AH109A (r=0.87; P<0.001) and AH272 (r = 0.86; P<0.001). The rate of increase in this pressure differed between AH109A and AH272 (P<0.001). It is concluded that the elevated interstitial fluid pressure in tumors could induce central necrosis and attenuate drug delivery to tumor tissue.

Original languageEnglish
Pages (from-to)65-73
Number of pages9
JournalJapanese Journal of Cancer Research GANN
Volume77
Issue number1
Publication statusPublished - 1986 Jan 1

Keywords

  • Diffusion chamber technique
  • Drug delivery
  • Necrosis
  • Tumor interstitial fluid pressure

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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