Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters

Tomohiro Sawa, Mounia Mounawar, Masayuki Tatemichi, Isabelle Gilibert, Takahiko Katoh, Hiroshi Ohshima

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Microsatellite polymorphism in the promoter region of the heme oxygenase-1 (HO-1) gene was analyzed jointly with that of the inducible nitric oxide synthase (iNOS) gene among Japanese subjects (control and gastric cancer patients). A higher promoter activity genotype of the HO-1 gene was associated with increased risk for gastric cancer in women. Gastric cancer risk was notably increased in subjects carrying a higher promoter activity genotype for both HO-1 and iNOS compared to those with a lower promoter activity genotype for both genes. Our data suggest that genetic polymorphisms of HO-1 and iNOS modulate individual susceptibility to gastric cancer risk.

Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalCancer Letters
Volume269
Issue number1
DOIs
Publication statusPublished - 2008 Sep 28

Keywords

  • Gastric cancer
  • Heme oxygenase-1
  • Inducible nitric oxide synthase
  • Inflammation
  • Polymorphism

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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