Increased ratio of soluble fibrin formation/thrombin generation in patients with DIC

Shigeki Kushimoto, Hideo Wada, Kazuo Kawasugi, Kohji Okamoto, Toshimasa Uchiyama, Yoshinobu Seki, Tsuyoshi Hatada, Hiroshi Imai, Tsutomu Nobori

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The generation of thrombin-antithromin (AT) complex (TAT) or soluble fibrin (SF) was prospectively compared with prothrombin fragment 1 + 2 (F1 + 2) generation in patients with disseminated intravascular coagulation (DIC). The plasma levels of TAT, SF, and F1 + 2 were significantly higher in the DIC group than in the non-DIC group. The differences in these levels between the DIC group and non-DIC group were significantly related to infections and hematopoietic tumors. There were no significant differences in the TAT/F1 + 2 ratio between DIC and non-DIC patients, but the SF/F1 + 2 ratio was significantly higher in the DIC group than the non-DIC group. The plasma AT activity was significantly higher in patients with DIC with resolution than in those without resolution, and in survivors than in nonsurvivors. These findings suggest that the ratio of TAT/thrombin is constant between the patients with and without DIC but that the ratio of fibrin formation/thrombin might increase in DIC.

Original languageEnglish
Pages (from-to)628-632
Number of pages5
JournalClinical and Applied Thrombosis/Hemostasis
Volume18
Issue number6
DOIs
Publication statusPublished - 2012 Nov

Keywords

  • DIC
  • antithrombin (AT)
  • prothrombin fragment F1 + 2
  • soluble fibrin (SF)
  • thrombin-AT complex

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Increased ratio of soluble fibrin formation/thrombin generation in patients with DIC'. Together they form a unique fingerprint.

Cite this