Increased postprandial colonic motility and autonomic nervous system activity in patients with irritable bowel syndrome: A prospective study

Yukari Tanaka, Motoyori Kanazawa, Olafur S. Palsson, Miranda A. Van Tilburg, Lisa M. Gangarosa, Shin Fukudo, Douglas A. Drossman, William E. Whitehead

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background/Aims The prevalence and severity of irritable bowel syndrome (IBS) declines with age, but the cause of this is unknown. This study tested 2 hypotheses: (1) autonomic nervous system responses to eating and bowel distention, measured by heart rate variability (HRV), differs by age in IBS patients and (2) HRV is correlated with colonic motility and IBS symptoms. Methods One hundred and fifty-six Rome III positive IBS patients and 31 healthy controls underwent colonic manometry with bag distention in the descending colon, followed by ingestion of an 810-kcal meal. HRV, evaluated by low frequency (%LF; 0.04-0.15 Hz) component, high frequency (%HF; 0.15-0.40 Hz) component, and the LF/HF ratio, was measured during colonic distention and after the meal. Motility index and subjective symptom scores were simultaneously quantified. Results Both colonic distention and eating decreased %HF and increased the LF/HF ratio, and both indices of autonomic nervous system correlated with age. In IBS patients, %HF negatively correlated with the postprandial motility index after adjusting for age. The %HF and LF/HF ratios also correlated with psychological symptoms but not bowel symptoms in IBS patients. Conclusion Decreased vagal activity is associated with increase in age and greater postprandial colonic motility in patients with IBS, which may contribute to postprandial symptoms.

Original languageEnglish
Pages (from-to)87-95
Number of pages9
JournalJournal of Neurogastroenterology and Motility
Volume24
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Keywords

  • Autonomic nervous system
  • Gastrointestinal Motility
  • Irritable bowel syndrome
  • Postprandial period

ASJC Scopus subject areas

  • Clinical Neurology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Increased postprandial colonic motility and autonomic nervous system activity in patients with irritable bowel syndrome: A prospective study'. Together they form a unique fingerprint.

Cite this