Increased plasma immunoreactive neuropeptide y concentrations in phaeochromocytoma and chronic renal failure

Kazuhiro Takahashi, Toraichi Mouri, Keiichi Itoi, Masahiko Sone, Makoto Ohneda, Osamu Murakami, Mitsuru Nozuki, Yoshiro Tachibana, Kaoru Yoshinaga

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33 Citations (Scopus)

Abstract

To investigate the clinical usefulness of radio-immunoassay of neuropeptide Y (NPY), we measured plasma immunoreactive neuropeptide Y (IR-NPY) concentrations in normal subjects (n = 21), essential hypertensive patients (n = 33), patients with phaeochromocytoma (n = 7), patients with chronic renal disease with serum creatinine levels of < 1.9mg/dl (n = 5) and patients with chronic renal failure whose serum creatinine levels were ≥ 1.9 mg/dl (n = 18, eight without haemodialysis and 10 undergoing maintenance haemodialysis), by radio-immunoassay. Plasma IR-NPY concentrations in patients with phaeochromocytoma (577 ± 256 pg/ml, mean ± s.d.) were significantly higher (P < 0.001) than those in normal subjects (151 ± 28 pg/ml), essential hypertensive patients (177 ± 49 pg/ml) and patients with chronic renal disease with serum creatinine levels < 1.9 mg/dl (198 ± 71 pg/ml). Plasma IR-NPY concentrations in patients with chronic renal failure (without haemodialysis: 330 ± 63 pg/ml; undergoing maintenance haemodialysis: 374 ± 80 pg/ml) were also high. These results suggest that NPY is useful as one of the tumour markers of phaeochromocytomas. However, this study revealed that patients with chronic renal failure, without phaeochromocytoma also have increased plasma IR-NPY concentrations.

Original languageEnglish
Pages (from-to)749-753
Number of pages5
JournalJournal of hypertension
Volume5
Issue number6
DOIs
Publication statusPublished - 1987 Dec

Keywords

  • Chronic renal failure
  • Maintenance haemodialysis
  • Neuropeptide Y
  • Phaeochromocytoma

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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