Increased phagocytosis of platelets from patients with secondary dengue virus infection by human macrophages

Shoko Honda, Mariko Saito, Efren M. Dimaano, Philip A. Morales, Maria T.G. Alonzo, Lady Anne C. Suarez, Natsuki Koike, Shingo Inoue, Atsushi Kumatori, Ronald R. Matias, Filipinas F. Natividad, Kazunori Oishi

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

The relationship between the percent phagocytosis of platelets by differentiated THP-1 cells was examined using flowcytometry and the peripheral platelet counts as well as platelet-associated IgG (PAIgG) in 36 patients with secondary dengue virus (DV) infections. The percent phagocytosis and the levels of PAIgG were significantly increased in these patients during the acute phase compared with the healthy volunteers. The increased percent phagocytosis and PAIgG found during the acute phase significantly decreased during the convalescent phase. An inverse correlation between platelet count and the percent phagocytosis (P=0.011) and the levels of PAIgG (P=0.041) was found among these patients during the acute phase. No correlation was found, however, between the percent phagocytosis and the lev-els of PAIgG. Our present data suggest that accelerated platelet phagocytosis occurs during the acute phase of secondary DV infections, and it is one of the mechanisms of thrombocytopenia in this disease.

Original languageEnglish
Pages (from-to)841-845
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume80
Issue number5
DOIs
Publication statusPublished - 2009 May
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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