Increased hypothalamic 5-HT2A receptor gene expression and effects of pharmacologic 5-HT2A receptor inactivation in obese Ay mice

Katsunori Nonogaki, Kana Nozue, Yoshitomo Oka

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Serotonin (5-hydroxytryptamine; 5-HT) 2A receptors contribute to the effects of 5-HT on platelet aggregation and vascular smooth muscle cell proliferation, and are reportedly involved in decreases in plasma levels of adiponectin, an adipokine, in diabetic subjects. Here, we report that systemic administration of sarpogrelate, a 5-HT2A receptor antagonist, suppressed appetite and increased hypothalamic pro-opiomelanocortin and cocaine- and amphetamine-regulated transcript, corticotropin releasing hormone, 5-HT2C, and 5-HT1B receptor gene expression. Ay mice, which have ectopic expression of the agouti protein, significantly increased hypothalamic 5-HT2A receptor gene expression in association with obesity compared with wild-type mice matched for age. Systemic administration of sarpogrelate suppressed overfeeding, body weight gain, and hyperglycemia in obese Ay mice, whereas it did not increase plasma adiponectin levels. These results suggest that obesity increases hypothalamic 5-HT2A receptor gene expression, and pharmacologic inactivation of 5-HT2A receptors inhibits overfeeding and obesity in Ay mice, but did not increase plasma adiponectin levels.

Original languageEnglish
Pages (from-to)1078-1082
Number of pages5
JournalBiochemical and biophysical research communications
Volume351
Issue number4
DOIs
Publication statusPublished - 2006 Dec 29

Keywords

  • 5-HT2A receptor
  • 5-HT2C receptor
  • A mice
  • Adiponectin
  • Cocaine- and amphetamine-regulated transcript
  • Corticotropin releasing hormone
  • Hyperglycemia
  • Obesity
  • Pro-opiomelanocortin
  • Sarpogrelate

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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