Increased expression of vascular endothelial growth factor in placentas of p57Kip2 null embryos

Toshiki Matsuura, Katsuhiko Takahashi, Keiko Nakayama, Takao Kobayashi, Nam Ho Choi-Miura, Motowo Tomita, Naohiro Kanayama

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Placentas of mice lacking p57Kip2 expression have trophoblastic hyperplasia. To elucidate the mechanism underlying this phenomenon, we studied expression of two angiogenic factors, vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF). Immunohistochemical analysis with anti-VEGF antibodies indicated that VEGF expression was stronger and more clearly detectable in placentas of p57Kip2 null embryos compared to wild-type placentas. PlGF showed no significant differences between placentas of p57Kip2 null and wild-type embryos. In quantitative analysis, placentas of p57Kip2 null embryos showed higher VEGF messenger (m)RNA and protein levels than did wild-type placentas. PlGF mRNA and protein levels were not significantly different. These findings suggest that VEGF is involved in the hyperplasia that occurs in placentas of p57Kip2 null embryos.

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalFEBS Letters
Issue number3
Publication statusPublished - 2002 Dec 18


  • Genomic imprinting
  • Placentation
  • Preeclampsia
  • VEGF
  • p57

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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