Increased expression of the mRNA for brain- and skin-type but not heart-type fatty acid binding proteins following kainic acid systemic administration in the hippocampal glia of adult rats

Yuji Owada, Takashi Yoshimoto, Hisatake Kondo

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Increased gene expression for two species of cytosolic fatty acid binding proteins (FABPs) after systemic administration of kainic acid in the rat brain was demonstrated by Northern blotting and in situ hybridization histochemical analyses. The expression of brain (B)- and skin (S)- but not heart (H)-FABP mRNAs were markedly elevated in the hippocampus at 48 h after systemic kainate treatment. The elevated expression patterns of B- and S-FABP mRNAs were quite similar to that for glial fibrillary acidic protein in the normal brain, suggesting strongly that the increased expression for B- and S-FABPs occurs in dedifferentiated and proliferated astrocytes in response to kainic acid-induced seizure.

Original languageEnglish
Pages (from-to)156-160
Number of pages5
JournalMolecular Brain Research
Volume42
Issue number1
DOIs
Publication statusPublished - 1996 Nov

Keywords

  • Astrocyte
  • Hybridization, in situ
  • Kainic acid
  • Northern blot analysis
  • mRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Increased expression of the mRNA for brain- and skin-type but not heart-type fatty acid binding proteins following kainic acid systemic administration in the hippocampal glia of adult rats'. Together they form a unique fingerprint.

Cite this