Increased expression of soluble form of vascular cell adhesion molecule-1 aggravates autoimmune arthritis in MRL-Faslpr mice

Hisashi Oishi, Shinichi Mizuki, Miho Terada, Megumi Kudo, Kimi Araki, Masatake Araki, Masato Nose, Satoru Takahashi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Vascular cell adhesion molecule-1 (VCAM-1, CD106) is important in leukocyte trafficking and its increased expression is associated with a number of chronic inflammatory diseases, including rheumatoid arthritis (RA). A soluble form of VCAM-1 (sVCAM-1) is generated by shedding of the membrane-bound molecule. The concentration of sVCAM-1 is increased in the sera of RA patients, but its pathological role has not been elucidated. The effect of sVCAM-1 relative to protection or aggravation of disease on the development of spontaneous arthritis was examined in an animal model of RA, namely MRL-Faslpr mice (which display a disease resembling human RA), by generation of sVCAM-1 transgenic MRL-Faslpr mice. Transgenic MRL-Faslpr mice that expressed sVCAM-1 had higher incidence and increased severity of arthritis associated with higher levels of serum IgG rheumatoid factor compared with non-transgenic MRL-Faslpr mice. These results suggest that sVCAM-1 plays an arthritogenic role in the development of inflammatory arthritis in MRL-Fas lpr mice and may present an important target for therapeutic strategy of RA.

Original languageEnglish
Pages (from-to)734-740
Number of pages7
JournalPathology international
Volume57
Issue number11
DOIs
Publication statusPublished - 2007 Nov 1

Keywords

  • Autoimmunity
  • CD106
  • MRL mouse
  • Mouse model
  • Rheumatoid arthritis
  • Rheumatoid factor
  • Vascular cell adhesion molecule-1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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