Increased expression of highly sulfated keratan sulfate synthesized in malignant astrocytic tumors

Yukinari Kato, Norihito Hayatsu, Mika Kato Kaneko, Satoshi Ogasawara, Tetsutaro Hamano, Satoru Takahashi, Ryo Nishikawa, Masao Matsutani, Kazuhiko Mishima, Hisashi Narimatsu

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Keratan sulfate (KS) proteoglycans are expressed on a subpopulation of microglia in normal adult brain. We previously showed the up-regulated expression of KS in one of glioblastoma cell lines using anti-KS antibody (5D4). However, it has not been clarified whether KS is expressed in brain tumors and is involved in their malignancy. In this study, 54 astrocytic tumors were investigated about KS-expression using Western-blot with 5D4. In six of 14 anaplastic astrocytomas (43%) and 23 of 34 glioblastomas (68%), KS was detected by 5D4. KS was hardly detected by 5D4 in diffuse astrocytoma, suggesting that KS-expression is significantly expressed in malignant astrocytic tumors. In immunohistochemistry, KS is highly expressed in cell surface of malignant astrocytic tumors. Taken together, KS might be associated with the malignancy of astrocytic tumors, and be useful for a prognostic factor of astrocytic tumors.

Original languageEnglish
Pages (from-to)1041-1046
Number of pages6
JournalBiochemical and biophysical research communications
Volume369
Issue number4
DOIs
Publication statusPublished - 2008 May 16
Externally publishedYes

Keywords

  • Astrocytic tumor
  • Glioblastoma
  • Glycogene
  • Keratan sulfate
  • Proteoglycan

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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