Increased expression of adrenomedullin mRNA in the tissues of intraocular and orbital tumors

Tetsuo Udono, Kazuhito Totsune, Kazuhiro Takahashi, Toshiaki Abe, Masami Sato, Shigeki Shibahara, Makoto Tamai

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

PURPOSE: To explore the possible involvement of adrenomedullin in the pathophysiology of intraocular and orbital tumors. METHODS: Competitive reverse transcription-polymerase chain reaction was used to determine adrenomedullin mRNA levels in the tissues from 40 consecutive patients (40 eyes) undergoing vitrectomy, orbital tissue biopsy, or enucleation for various ocular diseases, including intraocular (n = 4) and orbital (n = 3) tumors, proliferative vitreoretinopathy (n = 8), proliferative diabetic retinopathy (n = 8), age-related macular degeneration (n = 4), preretinal macular fibrosis (n = 9), and acute retinal necrosis (n = 4). RESULTS: Adrenomedullin mRNA levels in the tissues obtained from patients with intraocular or orbital tumors were significantly higher than those of patients with proliferative vitreoretinopathy (P < .05), proliferative diabetic retinopathy (P < .05), preretinal macular fibrosis (P < .005), and acute retinal necrosis (P < .01). CONCLUSION: Adrenomedullin may play a role in the pathophysiology of intraocular and orbital tumors. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)555-556
Number of pages2
JournalAmerican Journal of Ophthalmology
Volume129
Issue number4
DOIs
Publication statusPublished - 2000 Apr

ASJC Scopus subject areas

  • Ophthalmology

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