Increased arterial carboxyhemoglobin concentrations in chronic obstructive pulmonary disease

Hiroyasu Yasuda, Mutsuo Yamaya, Katsutoshi Nakayama, Satoru Ebihara, Takahiko Sasaki, Shoji Okinaga, Daisuke Inoue, Masanori Asada, Miyako Nemoto, Hidetada Sasaki

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Rationale: Exhaled carbon monoxide (CO) and arterial blood carboxyhemoglobin concentrations (Hb-CO) Increase In Inflammatory pulmonary diseases. Objectives: To study whether arterial Hb-CO Is useful to monitor disease activity In patients with chronic obstructive pulmonary disease (COPD) who had stopped smoking. Methods: We measured arterial Hb-CO, arterlovenous Hb-CO differences, and FEV, In 58 patients with COPD and 61 ex-smoking control subjects. Results: Arterial Hb-CO concentrations In patients at stable conditions were higher than those In control subjects (p < 0.0001). Furthermore, the Hb-CO concentrations In patients at the exacerbations (p < 0.0001) were higher than those at the stable conditions. Arterial Hb-CO concentrations In patients at stage III were higher than those In patients at stage II, and the Hb-CO concentrations In patients at stage IV were higher than those in patients at stage III at the stable conditions and exacerbations. Arterial Hb-CO correlated with exhaled CO In patients with COPD at stage II and stage III at the exacerbations. Arterial Hb-CO inversely correlated with the arterial blood partial oxygen pressure and FEV1. Arterlovenous Hb-CO differences in patients at the exacerbations did not differ from those In patients at stable conditions and from those In control subjects. Moreover, arterial Hb-CO correlated with serum C-reactive protein values and serum lipld peroxide concentrations. Conclusions: These findings suggest that increased arterial Hb-CO may relate to severity In patients with COPD because of lung and systemic inflammation and production of reactive oxygen species.

Original languageEnglish
Pages (from-to)1246-1251
Number of pages6
JournalAmerican journal of respiratory and critical care medicine
Volume171
Issue number11
DOIs
Publication statusPublished - 2005 Jun 1

Keywords

  • Carbon monoxide
  • Carboxyhemoglobin
  • Chronic obstructive pulmonary disease
  • Heme oxygenase
  • Systemic inflammation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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  • Cite this

    Yasuda, H., Yamaya, M., Nakayama, K., Ebihara, S., Sasaki, T., Okinaga, S., Inoue, D., Asada, M., Nemoto, M., & Sasaki, H. (2005). Increased arterial carboxyhemoglobin concentrations in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine, 171(11), 1246-1251. https://doi.org/10.1164/rccm.200407-914OC