Increase of liver heme concentration after the administration of insulin, glucagon and dibutyryl cyclic AMP to rats and its relevance to regulation of δ-aminolevulinate synthase

M. Yamamoto, N. Hayashi, G. Kikuchi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The administration of either insulin, glucagon or dibutyryl cyclic AMP to rats significantly decreases the activity of δ-aminolevulinate synthase in liver mitochondria. The administration of those substances was found to also cause a considerable increase in the degree of heme saturation of tryptophan pyrrolase, suggesting the increase in liver heme concentration. The regulatory effects of those substances on δ-aminolevulinate synthase may be well accounted for by the increase in liver heme concentration.

Original languageEnglish
Pages (from-to)747-754
Number of pages8
JournalBiochemistry international
Volume5
Issue number6
Publication statusPublished - 1982 Jan 1

ASJC Scopus subject areas

  • Biochemistry

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