TY - JOUR
T1 - Increase of glucose uptake in human bone marrow with increasing exercise intensity
AU - Heinonen, Ilkka
AU - Kemppainen, Jukka
AU - Fujimoto, Toshihiko
AU - Knuuti, Juhani
AU - Kalliokoski, Kari K.
N1 - Funding Information:
The study was conducted within the Centre of Excellence in Molecular Imaging in Cardiovascular and Metabolic Research-supported and funded by the Academy of Finland, University of Turku, Turku University Hospital, and Abo Academy. The authors thank the contribution of the personnel of the Turku PET Centre for their excellent assistance during the study and the subjects who participated. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study. The English language proofreading service for this manuscript was provided by Robert M. Badeau, M.Sc., Ph.D., of Aura Professional English Consulting, Ltd. All authors declare that they have no conflict of interest.
Funding Information:
The study was conducted within the Centre of Excellence in Molecular Imaging in Cardiovascular and Metabolic Research—supported and funded by the Academy of Finland, University of Turku, Turku University Hospital, and Abo Academy. The authors thank the contribution of the personnel of the Turku PET Centre for their excellent assistance during the study and the subjects who participated. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.
Publisher Copyright:
© 2019 Human Kinetics, Inc.
PY - 2019/5
Y1 - 2019/5
N2 - Human bone marrow is a metabolically active tissue that responds to acute low-intensity exercise by having increased glucose uptake (GU). Here, the authors studied whether bone marrow GU increases more with increased exercise intensities. Femoral bone marrow GU was measured using positron emission tomography and [18F]-fluorodeoxyglucose in six healthy young men during cycling at intensities of 30% (low), 55% (moderate), and 75% (high) of maximal oxygen consumption on three separate days. Bone marrow GU at low was 17.2 μmol·kg−1·min−1 (range 9.0-25.4) and increased significantly (p = .003) at moderate (31.2 μmol·kg−1·min−1, 22.9-39.4) but was not significant from moderate to high (37.4 μmol·kg−1·min−1, 29.0-45.7, p = .26). Furthermore, the ratio between bone and muscle GU decreased from low to moderate exercise intensity (p < .01) but not (p = .99) from moderate to high exercise intensity. In conclusion, these results show that although the increase is not as large as observed in exercising skeletal muscle, GU in femoral bone marrow increases with increasing exercise intensity at least from low- to moderate-intensity effort, which may be important for bone and whole-body metabolic health.
AB - Human bone marrow is a metabolically active tissue that responds to acute low-intensity exercise by having increased glucose uptake (GU). Here, the authors studied whether bone marrow GU increases more with increased exercise intensities. Femoral bone marrow GU was measured using positron emission tomography and [18F]-fluorodeoxyglucose in six healthy young men during cycling at intensities of 30% (low), 55% (moderate), and 75% (high) of maximal oxygen consumption on three separate days. Bone marrow GU at low was 17.2 μmol·kg−1·min−1 (range 9.0-25.4) and increased significantly (p = .003) at moderate (31.2 μmol·kg−1·min−1, 22.9-39.4) but was not significant from moderate to high (37.4 μmol·kg−1·min−1, 29.0-45.7, p = .26). Furthermore, the ratio between bone and muscle GU decreased from low to moderate exercise intensity (p < .01) but not (p = .99) from moderate to high exercise intensity. In conclusion, these results show that although the increase is not as large as observed in exercising skeletal muscle, GU in femoral bone marrow increases with increasing exercise intensity at least from low- to moderate-intensity effort, which may be important for bone and whole-body metabolic health.
KW - Humans
KW - Metabolism
KW - PET
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U2 - 10.1123/ijsnem.2018-0094
DO - 10.1123/ijsnem.2018-0094
M3 - Article
C2 - 30160564
AN - SCOPUS:85065564752
VL - 29
SP - 254
EP - 258
JO - International Journal of Sport Nutrition and Exercise Metabolism
JF - International Journal of Sport Nutrition and Exercise Metabolism
SN - 1526-484X
IS - 3
ER -
