Increase of complement fragment C5a in cerebrospinal fluid during exacerbation of neuromyelitis optica

Hiroshi Kuroda, Kazuo Fujihara, Rina Takano, Yoshiki Takai, Toshiyuki Takahashi, Tatsuro Misu, Ichiro Nakashima, Shigeru Sato, Yasuto Itoyama, Masashi Aoki

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Complement is thought to play a pivotal role in neuromyelitis optica (NMO) pathogenesis. Anaphylatoxins (C3a, C4a, and C5a), produced in complement activation, have proinflammatory potential, and thereby may play an important role. We measured concentrations of anaphylatoxins in CSF and sera, obtained from patients with NMO (n = 15), multiple sclerosis (MS) (n = 15), and other neurological disease (OND) (n = 12), and evaluated their clinical implications. The CSF-C5a levels were elevated significantly in NMO patients, especially in patients with multiple enhanced lesions on MRI. The CSF-C5a levels correlated with the severity of exacerbation. Our results may provide a rationale for anti-complement therapies of NMO.

Original languageEnglish
Pages (from-to)178-182
Number of pages5
JournalJournal of Neuroimmunology
Volume254
Issue number1-2
DOIs
Publication statusPublished - 2013 Jan 15

Keywords

  • Anaphylatoxins
  • C5a
  • Cerebrospinal fluid
  • Complement
  • Neuromyelitis optica
  • Relapse

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Increase of complement fragment C5a in cerebrospinal fluid during exacerbation of neuromyelitis optica'. Together they form a unique fingerprint.

Cite this