Increase of Cl- secretion induced by Kampo medicine (Japanese herbal medicine), Sai-rei-to, in Mongolian gerbil middle ear epithelium

Katsuhisa Ikeda, Masayuki Furukawa, Noriko Tanno, Mutsuo Yamaya, Tomonori Takasaka

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Sai-rei-to, a type of Kampo medicine (Japanese herbal medicine), has been shown to be clinically effective in treating patients with otitis media with effusion. The effect of Sai-rei-to on the ion transport of the middle ear surface epithelium cultured from the Mongolian gerbil was investigated by using an Ussing chamber. Application of Sai-rei-to to the mucosal bath but not the serosal bath induced an increase in the short-circuit current (I(SC)) in the basal state. The increase in I(SC) was almost completely inhibited by addition of diphenylamine-2-carboxylic acid but not by amiloride, indicating enhancement of Cl- secretion. On the basis of the lack of changes in the intracellular Ca2+ concentration and a sideness of action, the effect of Sai-rei-to on I(SC) is thought to be a direct and selective activation on the apical Cl- channel.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalJapanese Journal of Pharmacology
Volume73
Issue number1
DOIs
Publication statusPublished - 1997
Externally publishedYes

Keywords

  • Basal secretion
  • Cl secretion
  • Mucociliary transport
  • Otitis media with effusion
  • Short-circuit current

ASJC Scopus subject areas

  • Pharmacology

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