Abstract
Sai-rei-to, a type of Kampo medicine (Japanese herbal medicine), has been shown to be clinically effective in treating patients with otitis media with effusion. The effect of Sai-rei-to on the ion transport of the middle ear surface epithelium cultured from the Mongolian gerbil was investigated by using an Ussing chamber. Application of Sai-rei-to to the mucosal bath but not the serosal bath induced an increase in the short-circuit current (I(SC)) in the basal state. The increase in I(SC) was almost completely inhibited by addition of diphenylamine-2-carboxylic acid but not by amiloride, indicating enhancement of Cl- secretion. On the basis of the lack of changes in the intracellular Ca2+ concentration and a sideness of action, the effect of Sai-rei-to on I(SC) is thought to be a direct and selective activation on the apical Cl- channel.
Original language | English |
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Pages (from-to) | 29-32 |
Number of pages | 4 |
Journal | Japanese Journal of Pharmacology |
Volume | 73 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1997 |
Externally published | Yes |
Keywords
- Basal secretion
- Cl secretion
- Mucociliary transport
- Otitis media with effusion
- Short-circuit current
ASJC Scopus subject areas
- Pharmacology