Increase in histamine production by inflammatory exudate in the chronic phase of allergic inflammation in rats

Noriyasu Hirasawa, Muneshige Shiraishi, Shinji Oikawa, Suetsugu Mue, Kazuo Ohuchi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In the air pouch-type allergic inflammation in rats, we reported that a sustained histamine production in the late phase is induced by a cytokine-like factor, named histamine-production-increasing factor (HPIF). Recently, we found another type of histamine-production-increasing factor in the pouch fluid at the chronic phase of air pouch-type allergic inflammation. Although it did not increase histamine production by itself, it enhanced the HPIF-induced histamine production by rat bone marrow cells. It also increased GM-CSF-induced histamine production. The activity of this factor increased time-dependently from 3 to 7 days after the antigen challenge. Injection of the 5 day pouch fluid sample containing this factor into the pouch 4 h after the antigen challenge increased histamine contents in the pouch fluid at 24 h, indicating that this factor enhances HPIF-induced histamine production in vivo. Biochemical analysis of the 5 day pouch fluid sample indicated that this factor is a heat-labile and trypsin-sensitive protein of which pI value and molecular weight are 7-8 and about 100 kDa, respectively.

Original languageEnglish
Pages (from-to)471-482
Number of pages12
JournalInflammation
Volume22
Issue number5
DOIs
Publication statusPublished - 1998 Nov 12

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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