Incidence and characterization of age related amyloid deposits in the human anterior pituitary gland

Takatoshi Tashima, Tetsuyuki Kitamoto, Jun Tateishi, Koji Ogomori, Hiroyuki Nakagaki

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

To identify amyloid deposits in the anterior pituitary gland, we have immunohistochemical, histochemical and alkaline Congo red staining. The anti-human P component reacted positively with these amyloid deposits, while antisera against prealbumin, AA type amyloid fibril protein and various anterior pituitary hormones were negative. A combination of Congo red and anti-human P component staining was most sensitive and reliable for detection of amyloid in the anterior pituitary glands of 300 randomly autopsied patients. Amyloid deposits increased in parallel with the age of the patients, however, they appeared earlier and more frequently than heretofore reported. Deposition of amyloid was seen initially in the 3rd decade and the positivity rate of amyloid deposits was 73% in the 5th decade. The histochemical characteristics of these pituitary amyloid deposits differed from those of cerebral and systemic deposits, particularly those found in the amyloid of senile systemic amyloidosis.

Original languageEnglish
Pages (from-to)323-327
Number of pages5
JournalVirchows Archiv A Pathological Anatomy and Histopathology
Volume412
Issue number4
DOIs
Publication statusPublished - 1988 Jul 1
Externally publishedYes

Keywords

  • Aging
  • Amyloid
  • Amyloid P Component
  • Immunohistochemistry
  • Pituitary Gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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