In vivo visualization of tau deposits in corticobasal syndrome by 18 F-THK5351 PET

Akio Kikuchi, Nobuyuki Okamura, Takafumi Hasegawa, Ryuichi Harada, Shoichi Watanuki, Yoshihito Funaki, Kotaro Hiraoka, Toru Baba, Naoto Sugeno, Ryuji Oshima, Shun Yoshida, Junpei Kobayashi, Michinori Ezura, Michiko Kobayashi, Ohito Tano, Shunji Mugikura, Ren Iwata, Aiko Ishiki, Katsutoshi Furukawa, Hiroyuki AraiShozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Yukitsuka Kudo, Atsushi Takeda, Masashi Aoki

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Objective: To determine whether 18 F-THK5351 PET can be used to visualize tau deposits in brain lesions in live patients with corticobasal syndrome (CBS). Methods: We evaluated the in vitro binding of 3 H-THK5351 in postmortem brain tissues from a patient with corticobasal degeneration (CBD). In clinical PET studies, 18 F-THK5351 retention in 5 patients with CBS was compared to that in 8 age-matched normal controls and 8 patients with Alzheimer disease (AD). Results: 3 H-THK5351 was able to bind to tau deposits in the postmortem brain with CBD. In clinical PET studies, the 5 patients with CBS showed significantly higher 18 F-THK5351 retention in the frontal, parietal, and globus pallidus than the 8 age-matched normal controls and patients with AD. Higher 18 F-THK5351 retention was observed contralaterally to the side associated with greater cortical dysfunction and parkinsonism. Conclusions: 18 F-THK5351 PET demonstrated high tracer signal in sites susceptible to tau deposition in patients with CBS. 18 F-THK5351 should be considered as a promising candidate radiotracer for the in vivo imaging of tau deposits in CBS.

Original languageEnglish
Pages (from-to)2309-2316
Number of pages8
JournalNeurology
Volume87
Issue number22
DOIs
Publication statusPublished - 2016 Nov 29

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'In vivo visualization of tau deposits in corticobasal syndrome by 18 F-THK5351 PET'. Together they form a unique fingerprint.

  • Cite this

    Kikuchi, A., Okamura, N., Hasegawa, T., Harada, R., Watanuki, S., Funaki, Y., Hiraoka, K., Baba, T., Sugeno, N., Oshima, R., Yoshida, S., Kobayashi, J., Ezura, M., Kobayashi, M., Tano, O., Mugikura, S., Iwata, R., Ishiki, A., Furukawa, K., ... Aoki, M. (2016). In vivo visualization of tau deposits in corticobasal syndrome by 18 F-THK5351 PET. Neurology, 87(22), 2309-2316. https://doi.org/10.1212/WNL.0000000000003375