Abstract
A shock tube was utilized for transdermal delivery in fuzzy rats. Rhodamine-B dextran, 10 kDa molecular weight, was used as the probe molecule. Shock waves were generated by a two-stage shock tube. A single shock wave was applied onto the skin to permeabilize the stratum corneum. Subsequently, the dextran solution diffused through the stratum corneum into the epidermis. Fluorescence microscopy of biopsies showed that the dextran was delivered to a depth of 30-60 μm into the skin. Thus, the shock tube could become an inexpensive device for transdermal drug delivery.
| Original language | English |
|---|---|
| Pages (from-to) | 307-311 |
| Number of pages | 5 |
| Journal | Shock Waves |
| Volume | 10 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2000 Jan 1 |
| Externally published | Yes |
Keywords
- Shock tube
- Shock waves
- Stratum corneum permeability
- Stress waves
- Transdermal drug delivery
ASJC Scopus subject areas
- Mechanical Engineering
- Physics and Astronomy(all)
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Cite this
Lee, S., McAuliffe, D. J., Kodama, T., & Doukas, A. G. (2000). In vivo transdermal delivery using a shock tube. Shock Waves, 10(5), 307-311. https://doi.org/10.1007/s001930000059