In vivo transdermal delivery using a shock tube

S. Lee, D. J. McAuliffe, T. Kodama, A. G. Doukas

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A shock tube was utilized for transdermal delivery in fuzzy rats. Rhodamine-B dextran, 10 kDa molecular weight, was used as the probe molecule. Shock waves were generated by a two-stage shock tube. A single shock wave was applied onto the skin to permeabilize the stratum corneum. Subsequently, the dextran solution diffused through the stratum corneum into the epidermis. Fluorescence microscopy of biopsies showed that the dextran was delivered to a depth of 30-60 μm into the skin. Thus, the shock tube could become an inexpensive device for transdermal drug delivery.

Original languageEnglish
Pages (from-to)307-311
Number of pages5
JournalShock Waves
Volume10
Issue number5
DOIs
Publication statusPublished - 2000 Jan 1
Externally publishedYes

Keywords

  • Shock tube
  • Shock waves
  • Stratum corneum permeability
  • Stress waves
  • Transdermal drug delivery

ASJC Scopus subject areas

  • Mechanical Engineering
  • Physics and Astronomy(all)

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