In vivo transdermal delivery using a shock tube

S. Lee; D. J. McAuliffe; T. Kodama; A. G. Doukas

doi:10.1007/s001930000059

In vivo transdermal delivery using a shock tube

S. Lee, D. J. McAuliffe, T. Kodama, A. G. Doukas

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A shock tube was utilized for transdermal delivery in fuzzy rats. Rhodamine-B dextran, 10 kDa molecular weight, was used as the probe molecule. Shock waves were generated by a two-stage shock tube. A single shock wave was applied onto the skin to permeabilize the stratum corneum. Subsequently, the dextran solution diffused through the stratum corneum into the epidermis. Fluorescence microscopy of biopsies showed that the dextran was delivered to a depth of 30-60 μm into the skin. Thus, the shock tube could become an inexpensive device for transdermal drug delivery.

Original language	English
Pages (from-to)	307-311
Number of pages	5
Journal	Shock Waves
Volume	10
Issue number	5
DOIs	https://doi.org/10.1007/s001930000059
Publication status	Published - 2000 Jan 1
Externally published	Yes

Keywords

Shock tube
Shock waves
Stratum corneum permeability
Stress waves
Transdermal drug delivery

ASJC Scopus subject areas

Mechanical Engineering
Physics and Astronomy(all)

Access to Document

10.1007/s001930000059

Cite this

@article{cfdfe2cbde8449fb8925a906ecc513df,

title = "In vivo transdermal delivery using a shock tube",

abstract = "A shock tube was utilized for transdermal delivery in fuzzy rats. Rhodamine-B dextran, 10 kDa molecular weight, was used as the probe molecule. Shock waves were generated by a two-stage shock tube. A single shock wave was applied onto the skin to permeabilize the stratum corneum. Subsequently, the dextran solution diffused through the stratum corneum into the epidermis. Fluorescence microscopy of biopsies showed that the dextran was delivered to a depth of 30-60 μm into the skin. Thus, the shock tube could become an inexpensive device for transdermal drug delivery.",

keywords = "Shock tube, Shock waves, Stratum corneum permeability, Stress waves, Transdermal drug delivery",

author = "S. Lee and McAuliffe, {D. J.} and T. Kodama and Doukas, {A. G.}",

year = "2000",

month = jan,

day = "1",

doi = "10.1007/s001930000059",

language = "English",

volume = "10",

pages = "307--311",

journal = "Shock Waves",

issn = "0938-1287",

publisher = "Springer New York",

number = "5",

}

TY - JOUR

T1 - In vivo transdermal delivery using a shock tube

AU - Lee, S.

AU - McAuliffe, D. J.

AU - Kodama, T.

AU - Doukas, A. G.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - A shock tube was utilized for transdermal delivery in fuzzy rats. Rhodamine-B dextran, 10 kDa molecular weight, was used as the probe molecule. Shock waves were generated by a two-stage shock tube. A single shock wave was applied onto the skin to permeabilize the stratum corneum. Subsequently, the dextran solution diffused through the stratum corneum into the epidermis. Fluorescence microscopy of biopsies showed that the dextran was delivered to a depth of 30-60 μm into the skin. Thus, the shock tube could become an inexpensive device for transdermal drug delivery.

AB - A shock tube was utilized for transdermal delivery in fuzzy rats. Rhodamine-B dextran, 10 kDa molecular weight, was used as the probe molecule. Shock waves were generated by a two-stage shock tube. A single shock wave was applied onto the skin to permeabilize the stratum corneum. Subsequently, the dextran solution diffused through the stratum corneum into the epidermis. Fluorescence microscopy of biopsies showed that the dextran was delivered to a depth of 30-60 μm into the skin. Thus, the shock tube could become an inexpensive device for transdermal drug delivery.

KW - Shock tube

KW - Shock waves

KW - Stratum corneum permeability

KW - Stress waves

KW - Transdermal drug delivery

UR - http://www.scopus.com/inward/record.url?scp=0034358582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034358582&partnerID=8YFLogxK

U2 - 10.1007/s001930000059

DO - 10.1007/s001930000059

M3 - Article

AN - SCOPUS:0034358582

VL - 10

SP - 307

EP - 311

JO - Shock Waves

JF - Shock Waves

SN - 0938-1287

IS - 5

ER -

In vivo transdermal delivery using a shock tube

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this