In vivo synergy between green tea extract and levofloxacin against enterohemorrhagic Escherichia coli O157 infection

Emiko Isogai, Hiroshi Isogai, Kimiharu Hirose, Shunji Hayashi, Keiji Oguma

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

We studied the synergistic effects of Japanese green tea extract (JGTE) and levofloxacin (LVFX) against enterohemorrhagic Escherichia coli (EHEC) infection in a gnotobiotic mouse model. Mice fed on JGTE conferred a significant degree of protection against an oral challenge with EHEC. Complete elimination of the bacteria from the mice, was however, difficult. The combination of JGTE and LVFX increased the survival rate and reduced damage to target organs. Thus, dietary supplementation with JGTE improved the therapeutic effects of antibiotic treatment.

Original languageEnglish
Pages (from-to)248-251
Number of pages4
JournalCurrent Microbiology
Volume42
Issue number4
DOIs
Publication statusPublished - 2001 Jan 1

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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