In vivo Raman study of the living rat esophagus and stomach using a micro-Raman probe under an endoscope

Yusuke Hattori, Yuichi Komachi, Toru Asakura, Toru Shimosegawa, Gen Ichi Kanai, Hideo Tashiro, Hidetoshi Sato

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)

Abstract

A small endoscope system equipped with a micro Raman probe is developed for in vivo Raman measurements in living rats. The measurements are done under anesthesia and artificial respiration to minimize the impact on the rats. Raman spectra of living rat esophagus and stomach are successfully measured. Our results suggest that the Raman spectra reflect subsurface tissue structure that cannot be distinguished in the endoscope image. After the experiments, rats recover without any aftereffects. It is verified that the Raman measurement using the present system is safe and noninvasive for rats.

Original languageEnglish
Pages (from-to)579-584
Number of pages6
JournalApplied spectroscopy
Volume61
Issue number6
DOIs
Publication statusPublished - 2007 Jun

Keywords

  • Esophagus
  • In vivo Raman spectroscopy
  • Micro-raman probe
  • Miniaturized endoscope
  • Stomach

ASJC Scopus subject areas

  • Instrumentation
  • Spectroscopy

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