In vivo optical analysis of pancreatic cancer tissue in a living model mice using fluorescence and raman spectroscopic techniques

Toshiaki Suzuki, Yusuke Hattoria, Takashi Katagiria, Hiroki Mitsuokaa, Ken Ichi Sato, Toru Asakurab, Toru Shimosegawa, Hidetoshi Satoa

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)

Abstract

Living pancreatic cancer tissues grown subcutaneously in nude mice are studied by in vivo Raman spectroscopy and autofluorescence imaging. Comparing the same point spectra of alive pancreatic cancer tissue to that of the dead tissue, it is found that they are different each other. The results suggest that the spectral changes reflect the protein conformational changes in the tumor tissue with death of the host animal. From the result of autofluorescence study, in vivo autofluorescence imaging has potential as a method to assign the histological elements of the pancreatic cancer tissue without any staining. These results strongly suggest that combination of these techniques is very important to study biological tissue.

Original languageEnglish
Article number718202
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7182
DOIs
Publication statusPublished - 2009
EventImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII - San Jose, CA, United States
Duration: 2009 Jan 262009 Jan 28

Keywords

  • Autofluorescence imaging
  • In vivo experiment
  • Pancreatic cancer tissue
  • Raman spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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