In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent

Tatsuhiro Yamamoto, Kenjiro Ikuta, Keiji Oi, Kohtaro Abe, Toyokazu Uwatoku, Fuminori Hyodo, Masaharu Murata, Noboru Shigetani, Kengo Yoshimitsu, Hiroaki Shimokawa, Hideo Utsumi, Yoshiki Katayama

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.

Original languageEnglish
Pages (from-to)2787-2790
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number11
DOIs
Publication statusPublished - 2004 Jun 7

Keywords

  • Cardiovascular disease
  • MRI
  • MRI contrast agent
  • Vascular endothelial injury

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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