In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent

Tatsuhiro Yamamoto; Kenjiro Ikuta; Keiji Oi; Kohtaro Abe; Toyokazu Uwatoku; Fuminori Hyodo; Masaharu Murata; Noboru Shigetani; Kengo Yoshimitsu; Hiroaki Shimokawa; Hideo Utsumi; Yoshiki Katayama

doi:10.1016/j.bmcl.2004.03.066

In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent

Tatsuhiro Yamamoto, Kenjiro Ikuta, Keiji Oi, Kohtaro Abe, Toyokazu Uwatoku, Fuminori Hyodo, Masaharu Murata, Noboru Shigetani, Kengo Yoshimitsu, Hiroaki Shimokawa, Hideo Utsumi, Yoshiki Katayama

MED - Medical Sciences

Research output: Contribution to journal › Article

13 Citations (Scopus)

Abstract

A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.

Original language	English
Pages (from-to)	2787-2790
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2004.03.066
Publication status	Published - 2004 Jun 7

Keywords

Cardiovascular disease
MRI
MRI contrast agent
Vascular endothelial injury

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent. / Yamamoto, Tatsuhiro; Ikuta, Kenjiro; Oi, Keiji; Abe, Kohtaro; Uwatoku, Toyokazu; Hyodo, Fuminori; Murata, Masaharu; Shigetani, Noboru; Yoshimitsu, Kengo; Shimokawa, Hiroaki; Utsumi, Hideo; Katayama, Yoshiki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 11, 07.06.2004, p. 2787-2790.

Research output: Contribution to journal › Article

Yamamoto, Tatsuhiro ; Ikuta, Kenjiro ; Oi, Keiji ; Abe, Kohtaro ; Uwatoku, Toyokazu ; Hyodo, Fuminori ; Murata, Masaharu ; Shigetani, Noboru ; Yoshimitsu, Kengo ; Shimokawa, Hiroaki ; Utsumi, Hideo ; Katayama, Yoshiki. / In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent. In: Bioorganic and Medicinal Chemistry Letters. 2004 ; Vol. 14, No. 11. pp. 2787-2790.

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