In vivo mechanical properties of thoracic aortic aneurysmal wall estimated from in vitro biaxial tensile test

Tomohiro Fukui, Takeo Matsumoto, Toshihiro Tanaka, Toshiro Ohashi, Kiichiro Kumagai, Hiroji Akimoto, Koichi Tabayashi, Masaaki Sato

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To investigate the mechanism of aneurysm rupture, it is necessary to examine the mechanical properties of aneurysm tissues in vivo. A new approach to evaluate in vivo mechanical properties of aortic aneurysmal tissues has been proposed in this study. The shape of the aneurysm was modeled as a sphere, and equi-biaxial stress in the in vivo state was estimated from the diameter and the wall thickness of each aneurysm and mean blood pressure of each patient. The mechanical properties of the aneurysm at the in vivo stress were estimated from its in vitro biaxial tensile properties. There were no significant correlations among maximum diameter D, wall thickness t, and mean infinitesimal strain in the in vivo state εm. This indicates the wall deformation during aneurysm development was not elastic but plastic. The mean incremental elastic modulus Hm, an index of tissue stiffness, had a significant positive correlation with elastic modulus anisotropy index KH. This indicates the aneurysmal wall got more anisotropic in vivo as it becomes stiffer.

Original languageEnglish
Pages (from-to)295-305
Number of pages11
JournalBio-Medical Materials and Engineering
Volume15
Issue number4
Publication statusPublished - 2005 Jul 27

Keywords

  • Anisotropy
  • Aortic aneurysm
  • Equibiaxial property

ASJC Scopus subject areas

  • Medicine(all)
  • Biomaterials
  • Biomedical Engineering

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    Fukui, T., Matsumoto, T., Tanaka, T., Ohashi, T., Kumagai, K., Akimoto, H., Tabayashi, K., & Sato, M. (2005). In vivo mechanical properties of thoracic aortic aneurysmal wall estimated from in vitro biaxial tensile test. Bio-Medical Materials and Engineering, 15(4), 295-305.