In vivo measurements of glucose uptake in human Achilles tendon during different exercise intensities

J. Hannukainen, K. K. Kalliokoski, P. Nuutila, T. Fujimoto, J. Kemppainen, T. Viljanen, M. S. Laaksonen, R. Parkkola, J. Knuuti, M. Kjær

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Abstract

Muscular contraction and loading of adjacent tendons has been demonstrated to cause increased blood flow and metabolic activity in the peritendinous region. However, it is poorly known to what extent the human tendon itself takes up glucose during exercise. Thus, the purpose of this study was to measure tendon glucose uptake with increasing exercise intensity and to compare it to muscle glucose uptake at the same intensities. Eight young men were examined on three separate days during which they performed 35 min of cycling at 30, 55 and 75% of V̇O2max, respectively. Glucose uptake was measured directly by positron emission tomography (PET) with 2-[18F]fluoro-2- deoxyglucose ([18F]FDG). [18F]FDG was injected after 10 min of exercise that was continued for a further 25 min after the injection. PET scanning of the thigh and Achilles region was performed after the exercise. Glucose uptake of the Achilles tendon (AT) remained unchanged (7.1 ± 1.5, 6.6 ± 1.1, and 6.0 ± 1.1 μmol·kg -1·min-1) with the increasing workload, although the glucose uptake in m. quadriceps femoris simultaneously clearly increased (48 ± 35, 120 ± 35, and 152 ± 74 μmol·kg -1·min-1, p < 0.05). In conclusion, the AT takes up glucose during exercise but in significantly smaller amounts than the skeletal muscle does. Furthermore, glucose uptake in the AT is not increased with the increasing exercise intensity. This may be partly explained by the cycle ergometry exercise used in the present study, which probably causes only a little increase in strain to the AT with increasing exercise intensity.

Original languageEnglish
Pages (from-to)727-731
Number of pages5
JournalInternational Journal of Sports Medicine
Volume26
Issue number9
DOIs
Publication statusPublished - 2005 Nov 1

Keywords

  • Blood flow
  • Connective tissue
  • Metabolism

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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    Hannukainen, J., Kalliokoski, K. K., Nuutila, P., Fujimoto, T., Kemppainen, J., Viljanen, T., Laaksonen, M. S., Parkkola, R., Knuuti, J., & Kjær, M. (2005). In vivo measurements of glucose uptake in human Achilles tendon during different exercise intensities. International Journal of Sports Medicine, 26(9), 727-731. https://doi.org/10.1055/s-2005-837458