In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[11C]dimethyltryptamine

Kazuhiko Yanai; Tatsuo Ido; Kiichi Ishiwata; Jun Hatazawa; Toshihiro Takahashi; Ren Iwata; Taiju Matsuzawa

doi:10.1007/BF00276707

In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[¹¹C]dimethyltryptamine

Kazuhiko Yanai, Tatsuo Ido, Kiichi Ishiwata, Jun Hatazawa, Toshihiro Takahashi, Ren Iwata, Taiju Matsuzawa

MED - Medical Sciences

Research output: Contribution to journal › Article

11 Citations (Scopus)

Abstract

The endogenous hallucinogen, N,N-dimethyltryptamine (DMT), was labeled with carbon-11 and its regional distribution in rat brain studied. [¹¹C]DMT showed higher accumulation in the cerebral cortex, caudate putamen, and amygdaloid nuclei. Studies of the subcellular distribution of [¹¹C]DMT revealed the specific localization in the fractions enriched with serotonin receptors only when a very low dose was injected into rats. The proportions of the radioactivity in receptor-rich fractions were greatly enhanced by pretreatment with the monoamine oxidase inhibitor, pargyline. Specific binding of [¹¹C]DMT to serotonin receptors in dog brain was demonstrated by a positron emission tomographic study in which 5-methoxy-N,N-dimethyltryptamine caused approximately 20% displacement of the radioligand from the receptors.

Original language	English
Pages (from-to)	141-146
Number of pages	6
Journal	European Journal of Nuclear Medicine
Volume	12
Issue number	3
DOIs	https://doi.org/10.1007/BF00276707
Publication status	Published - 1986 Jul 1

Keywords

Positron
Serotonin receptors
[C]Dimethyltryptamine

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1007/BF00276707

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Yanai, K., Ido, T., Ishiwata, K., Hatazawa, J., Takahashi, T., Iwata, R., & Matsuzawa, T. (1986). In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[¹¹C]dimethyltryptamine. European Journal of Nuclear Medicine, 12(3), 141-146. https://doi.org/10.1007/BF00276707

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abstract = "The endogenous hallucinogen, N,N-dimethyltryptamine (DMT), was labeled with carbon-11 and its regional distribution in rat brain studied. [11C]DMT showed higher accumulation in the cerebral cortex, caudate putamen, and amygdaloid nuclei. Studies of the subcellular distribution of [11C]DMT revealed the specific localization in the fractions enriched with serotonin receptors only when a very low dose was injected into rats. The proportions of the radioactivity in receptor-rich fractions were greatly enhanced by pretreatment with the monoamine oxidase inhibitor, pargyline. Specific binding of [11C]DMT to serotonin receptors in dog brain was demonstrated by a positron emission tomographic study in which 5-methoxy-N,N-dimethyltryptamine caused approximately 20% displacement of the radioligand from the receptors.",

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AU - Yanai, Kazuhiko

AU - Ido, Tatsuo

AU - Ishiwata, Kiichi

AU - Hatazawa, Jun

AU - Takahashi, Toshihiro

AU - Iwata, Ren

AU - Matsuzawa, Taiju

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AB - The endogenous hallucinogen, N,N-dimethyltryptamine (DMT), was labeled with carbon-11 and its regional distribution in rat brain studied. [11C]DMT showed higher accumulation in the cerebral cortex, caudate putamen, and amygdaloid nuclei. Studies of the subcellular distribution of [11C]DMT revealed the specific localization in the fractions enriched with serotonin receptors only when a very low dose was injected into rats. The proportions of the radioactivity in receptor-rich fractions were greatly enhanced by pretreatment with the monoamine oxidase inhibitor, pargyline. Specific binding of [11C]DMT to serotonin receptors in dog brain was demonstrated by a positron emission tomographic study in which 5-methoxy-N,N-dimethyltryptamine caused approximately 20% displacement of the radioligand from the receptors.

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