In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[11C]dimethyltryptamine

Kazuhiko Yanai; Tatsuo Ido; Kiichi Ishiwata; Jun Hatazawa; Toshihiro Takahashi; Ren Iwata; Taiju Matsuzawa

doi:10.1007/BF00276707

In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[¹¹C]dimethyltryptamine

Kazuhiko Yanai, Tatsuo Ido, Kiichi Ishiwata, Jun Hatazawa, Toshihiro Takahashi, Ren Iwata, Taiju Matsuzawa

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The endogenous hallucinogen, N,N-dimethyltryptamine (DMT), was labeled with carbon-11 and its regional distribution in rat brain studied. [¹¹C]DMT showed higher accumulation in the cerebral cortex, caudate putamen, and amygdaloid nuclei. Studies of the subcellular distribution of [¹¹C]DMT revealed the specific localization in the fractions enriched with serotonin receptors only when a very low dose was injected into rats. The proportions of the radioactivity in receptor-rich fractions were greatly enhanced by pretreatment with the monoamine oxidase inhibitor, pargyline. Specific binding of [¹¹C]DMT to serotonin receptors in dog brain was demonstrated by a positron emission tomographic study in which 5-methoxy-N,N-dimethyltryptamine caused approximately 20% displacement of the radioligand from the receptors.

Original language	English
Pages (from-to)	141-146
Number of pages	6
Journal	European Journal of Nuclear Medicine
Volume	12
Issue number	3
DOIs	https://doi.org/10.1007/BF00276707
Publication status	Published - 1986 Jul

Keywords

Positron
Serotonin receptors
[C]Dimethyltryptamine

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1007/BF00276707

Cite this

@article{0235bd8feb9e470a967a25c443f68b3c,

title = "In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[11C]dimethyltryptamine",

abstract = "The endogenous hallucinogen, N,N-dimethyltryptamine (DMT), was labeled with carbon-11 and its regional distribution in rat brain studied. [11C]DMT showed higher accumulation in the cerebral cortex, caudate putamen, and amygdaloid nuclei. Studies of the subcellular distribution of [11C]DMT revealed the specific localization in the fractions enriched with serotonin receptors only when a very low dose was injected into rats. The proportions of the radioactivity in receptor-rich fractions were greatly enhanced by pretreatment with the monoamine oxidase inhibitor, pargyline. Specific binding of [11C]DMT to serotonin receptors in dog brain was demonstrated by a positron emission tomographic study in which 5-methoxy-N,N-dimethyltryptamine caused approximately 20% displacement of the radioligand from the receptors.",

keywords = "Positron, Serotonin receptors, [C]Dimethyltryptamine",

author = "Kazuhiko Yanai and Tatsuo Ido and Kiichi Ishiwata and Jun Hatazawa and Toshihiro Takahashi and Ren Iwata and Taiju Matsuzawa",

year = "1986",

month = jul,

doi = "10.1007/BF00276707",

language = "English",

volume = "12",

pages = "141--146",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

publisher = "Springer Verlag",

number = "3",

}

TY - JOUR

T1 - In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[11C]dimethyltryptamine

AU - Yanai, Kazuhiko

AU - Ido, Tatsuo

AU - Ishiwata, Kiichi

AU - Hatazawa, Jun

AU - Takahashi, Toshihiro

AU - Iwata, Ren

AU - Matsuzawa, Taiju

PY - 1986/7

Y1 - 1986/7

N2 - The endogenous hallucinogen, N,N-dimethyltryptamine (DMT), was labeled with carbon-11 and its regional distribution in rat brain studied. [11C]DMT showed higher accumulation in the cerebral cortex, caudate putamen, and amygdaloid nuclei. Studies of the subcellular distribution of [11C]DMT revealed the specific localization in the fractions enriched with serotonin receptors only when a very low dose was injected into rats. The proportions of the radioactivity in receptor-rich fractions were greatly enhanced by pretreatment with the monoamine oxidase inhibitor, pargyline. Specific binding of [11C]DMT to serotonin receptors in dog brain was demonstrated by a positron emission tomographic study in which 5-methoxy-N,N-dimethyltryptamine caused approximately 20% displacement of the radioligand from the receptors.

AB - The endogenous hallucinogen, N,N-dimethyltryptamine (DMT), was labeled with carbon-11 and its regional distribution in rat brain studied. [11C]DMT showed higher accumulation in the cerebral cortex, caudate putamen, and amygdaloid nuclei. Studies of the subcellular distribution of [11C]DMT revealed the specific localization in the fractions enriched with serotonin receptors only when a very low dose was injected into rats. The proportions of the radioactivity in receptor-rich fractions were greatly enhanced by pretreatment with the monoamine oxidase inhibitor, pargyline. Specific binding of [11C]DMT to serotonin receptors in dog brain was demonstrated by a positron emission tomographic study in which 5-methoxy-N,N-dimethyltryptamine caused approximately 20% displacement of the radioligand from the receptors.

KW - Positron

KW - Serotonin receptors

KW - [C]Dimethyltryptamine

UR - http://www.scopus.com/inward/record.url?scp=0023034836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023034836&partnerID=8YFLogxK

U2 - 10.1007/BF00276707

DO - 10.1007/BF00276707

M3 - Article

C2 - 3489620

AN - SCOPUS:0023034836

VL - 12

SP - 141

EP - 146

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

IS - 3

ER -