In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[11C]dimethyltryptamine

Kazuhiko Yanai, Tatsuo Ido, Kiichi Ishiwata, Jun Hatazawa, Toshihiro Takahashi, Ren Iwata, Taiju Matsuzawa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The endogenous hallucinogen, N,N-dimethyltryptamine (DMT), was labeled with carbon-11 and its regional distribution in rat brain studied. [11C]DMT showed higher accumulation in the cerebral cortex, caudate putamen, and amygdaloid nuclei. Studies of the subcellular distribution of [11C]DMT revealed the specific localization in the fractions enriched with serotonin receptors only when a very low dose was injected into rats. The proportions of the radioactivity in receptor-rich fractions were greatly enhanced by pretreatment with the monoamine oxidase inhibitor, pargyline. Specific binding of [11C]DMT to serotonin receptors in dog brain was demonstrated by a positron emission tomographic study in which 5-methoxy-N,N-dimethyltryptamine caused approximately 20% displacement of the radioligand from the receptors.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalEuropean Journal of Nuclear Medicine
Volume12
Issue number3
DOIs
Publication statusPublished - 1986 Jul 1

Keywords

  • Positron
  • Serotonin receptors
  • [C]Dimethyltryptamine

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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