TY - JOUR
T1 - In vivo induction of apoptosis and immune responses in mice by administration of lipopolysaccharide from Porphyromonas gingivalis
AU - Isogai, Emiko
AU - Isogai, Hiroshi
AU - Kimura, Koichi
AU - Fujii, Nobuhiro
AU - Takagi, Seiichi
AU - Hirose, Kimiharu
AU - Hayashi, Masanobu
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1996
Y1 - 1996
N2 - In vivo administration of Porphyromonas gingivalis lipopolysaccharide (Pg- LPS) to mice induced apoptosis before a specific immune response. Apoptosis was associated with the expression of immunoglobulin and Ia on B cells and of CD5 and several markers on T cells. Apoptosis peaked in the spleen and lymph nodes on day 2, and the second peak occurred in the thymus on day 9. Tumor necrosis factor alpha (TNF-α) could mediate apoptosis, because the serum TNF-α levels were significantly higher than those of controls at 1 day before apoptosis and recombinant murine TNF-α induced apoptosis. The apoptosis induced by Pg-LPS was similar to that induced by Escherichia coli LPS in its basic manner, but it was unique in the response of thymus T cells. It was suggested that Pg-LPS could induce apoptosis for the elimination of early nonspecific activated lymphocytes.
AB - In vivo administration of Porphyromonas gingivalis lipopolysaccharide (Pg- LPS) to mice induced apoptosis before a specific immune response. Apoptosis was associated with the expression of immunoglobulin and Ia on B cells and of CD5 and several markers on T cells. Apoptosis peaked in the spleen and lymph nodes on day 2, and the second peak occurred in the thymus on day 9. Tumor necrosis factor alpha (TNF-α) could mediate apoptosis, because the serum TNF-α levels were significantly higher than those of controls at 1 day before apoptosis and recombinant murine TNF-α induced apoptosis. The apoptosis induced by Pg-LPS was similar to that induced by Escherichia coli LPS in its basic manner, but it was unique in the response of thymus T cells. It was suggested that Pg-LPS could induce apoptosis for the elimination of early nonspecific activated lymphocytes.
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U2 - 10.1128/iai.64.4.1461-1466.1996
DO - 10.1128/iai.64.4.1461-1466.1996
M3 - Article
C2 - 8606120
AN - SCOPUS:0029923798
VL - 64
SP - 1461
EP - 1466
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 4
ER -