[In vivo experimental models of neuromyelitis optica]

Research output: Contribution to journalArticle

Abstract

Neuromyelitis optica (NMO) is autoimmune disease targeting against water channel aquaporin 4 (AQP4), mainly located at astrocyte foot processes in the central nervous system (CNS). The basis of NMO pathology is the astrocytopathy, but it is recently revealed that there is the diversity of NMO lesion possibly links to the mechanism of astrocyte death with and without complement. In vitro and in vivo models of NMO suggested that this autoantibody is pathogenic. There are mainly two types of in vivo experimental rodent models of NMO, one is a model of direct intracranial injection of NMO-IgG and the other is a passive transfer of NMO-IgG in experimental autoimmune encephalomyelitis (EAE). Both is useful to study the pathogenicity of NMO-IgG, and is promising to create the new generation therapy for autoimmune CNS diseases.

Original languageEnglish
Pages (from-to)1941-1948
Number of pages8
JournalNihon rinsho. Japanese journal of clinical medicine
Volume72
Issue number11
Publication statusPublished - 2014 Nov 1
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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