In vivo evaluation of a Ti-based bulk metallic glass alloy bar

Ryo Kokubun, Wei Wang, Shengli Zhu, Guoqiang Xie, Shizuko Ichinose, Soichiro Itoh, Kazuo Takakuda

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)


    Ti-based bulk metallic glasses are reported with high strength, low Young modulus and high corrosion resistance, suggesting their potentials in biomedical applications. However a thorough in vivo evaluation of its biocompatibilities has not been conducted yet. In this study, we implanted bars of Ti-based bulk metallic glass in the femoral bone of rats, followed up local tissue reaction as well as its component ions' diffusion in local area and whole body. The Ti-based BMG (Ti40Zr10Cu34Pd14Sn2) alloy exhibited favorable features of both high strength and high elasticity. In vivo implant evaluation showed that it has a good tissue compatibility, equivalent bone integration and bonding ability with Ti sample. No component ion diffusion was detected up to 3months post implantation. The possibility and efficacy of its use for bone implant is confirmed. Thus further long term implant study is recommended.

    Original languageEnglish
    Pages (from-to)9-17
    Number of pages9
    JournalBio-medical materials and engineering
    Issue number1-2
    Publication statusPublished - 2015 Oct 16


    • Bulk metallic glass
    • Ti-based alloy
    • in vivo

    ASJC Scopus subject areas

    • Biomaterials
    • Biomedical Engineering


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