In vivo evaluation of a Ti-based bulk metallic glass alloy bar

Ryo Kokubun; Wei Wang; Shengli Zhu; Guoqiang Xie; Shizuko Ichinose; Soichiro Itoh; Kazuo Takakuda

doi:10.3233/BME-151546

In vivo evaluation of a Ti-based bulk metallic glass alloy bar

Ryo Kokubun, Wei Wang, Shengli Zhu, Guoqiang Xie, Shizuko Ichinose, Soichiro Itoh, Kazuo Takakuda

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Ti-based bulk metallic glasses are reported with high strength, low Young modulus and high corrosion resistance, suggesting their potentials in biomedical applications. However a thorough in vivo evaluation of its biocompatibilities has not been conducted yet. In this study, we implanted bars of Ti-based bulk metallic glass in the femoral bone of rats, followed up local tissue reaction as well as its component ions' diffusion in local area and whole body. The Ti-based BMG (Ti₄₀Zr₁₀Cu₃₄Pd₁₄Sn₂) alloy exhibited favorable features of both high strength and high elasticity. In vivo implant evaluation showed that it has a good tissue compatibility, equivalent bone integration and bonding ability with Ti sample. No component ion diffusion was detected up to 3months post implantation. The possibility and efficacy of its use for bone implant is confirmed. Thus further long term implant study is recommended.

Original language	English
Pages (from-to)	9-17
Number of pages	9
Journal	Bio-medical materials and engineering
Volume	26
Issue number	1-2
DOIs	https://doi.org/10.3233/BME-151546
Publication status	Published - 2015 Oct 16

Keywords

Bulk metallic glass
Ti-based alloy
in vivo

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

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10.3233/BME-151546

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AU - Kokubun, Ryo

AU - Wang, Wei

AU - Zhu, Shengli

AU - Xie, Guoqiang

AU - Ichinose, Shizuko

AU - Itoh, Soichiro

AU - Takakuda, Kazuo

PY - 2015/10/16

Y1 - 2015/10/16

N2 - Ti-based bulk metallic glasses are reported with high strength, low Young modulus and high corrosion resistance, suggesting their potentials in biomedical applications. However a thorough in vivo evaluation of its biocompatibilities has not been conducted yet. In this study, we implanted bars of Ti-based bulk metallic glass in the femoral bone of rats, followed up local tissue reaction as well as its component ions' diffusion in local area and whole body. The Ti-based BMG (Ti40Zr10Cu34Pd14Sn2) alloy exhibited favorable features of both high strength and high elasticity. In vivo implant evaluation showed that it has a good tissue compatibility, equivalent bone integration and bonding ability with Ti sample. No component ion diffusion was detected up to 3months post implantation. The possibility and efficacy of its use for bone implant is confirmed. Thus further long term implant study is recommended.

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In vivo evaluation of a Ti-based bulk metallic glass alloy bar

Abstract

Keywords

ASJC Scopus subject areas

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