In vivo effects of isolated implantation of salmon-derived crosslinked atelocollagen sponge into an osteochondral defect

Yasuyuki Kawaguchi, Eiji Kondo, Nobuto Kitamura, Kazunobu Arakaki, Yasuhito Tanaka, Masanobu Munekata, Nobuhiro Nagai, Kazunori Yasuda

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

We have developed crosslinked salmon-derived atelocollagen (SC) sponge, which has a denaturation temperature of 47°C. Sixty-four knees of 32 mature rabbits were randomly divided into 4 groups after creating an osteochondral defect in the femoral trochlea. Defects in Groups I, II, and III were filled with the crosslinked SC sponge, the crosslinked porcine collagen (PC) sponge, and the non-crosslinked PC sponge, respectively. In Group IV, defects were left untreated as the control. At 12 weeks after implantation, the histological score showed that Group I was significantly greater than Groups III (P = 0.0196) and IV (P = 0.0021). In addition, gene expression of type-2 collagen, aggrecan, and SOX9 was the greatest in Group I at 12 weeks. The fundamental in vivo properties of the crosslinked SC sponge showed that this is a promising biomaterial, specifically as a scaffold for cartilage tissue engineering.

Original languageEnglish
Pages (from-to)397-404
Number of pages8
JournalJournal of Materials Science: Materials in Medicine
Volume22
Issue number2
DOIs
Publication statusPublished - 2011 Feb

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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