In vivo behavior of untreated and compressed concentrated growth factors as biomaterials in rabbits

Takeshi Tone, Yoshinaka Shimizu, Haruka Saito, Takumi Sato, Hidetoshi Ito, Yukyo Takada, Masatoshi Takahashi, Kenji Odashima, Mariko Oikawa, Tetsu Takahashi, Hiroyuki Kumamoto

Research output: Contribution to journalArticlepeer-review

Abstract

To characterize concentrated growth factors (CGFs) in vivo, we examined the degradation of implanted CGF in rabbits. Untreated CGF (U-CGF) and compressed CGF (C-CGF) were subcutaneously implanted into the dorsum. Histological analyses showed that the U-CGF and C-CGF induced very few inflammatory cells and that the U-CGF and C-CGF were subsequently degraded with dendritic invasion of granulation tissue. The C-CGF histopathologically remained for longer term than the U-CGF. Aggregated CD31+ and RAM11+ cells appeared in and around the implanted CGF. The number of macrophages and blood vessels in the CGF-implanted groups was greater than that in the sham group. There were more blood vessels in the U-CGF group than that in the C-CGF and sham group. We showed that CGF was degraded by macrophages in 4 weeks and enhanced angiogenesis with dendritically branching new capillaries. Therefore, the U-CGF and C-CGF can be clinically applied as a biomaterial inducing angiogenesis.

Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalDental materials journal
Volume40
Issue number1
DOIs
Publication statusPublished - 2021

Keywords

  • Concentrated growth factor
  • Tissue regeneration
  • Wound healing

ASJC Scopus subject areas

  • Ceramics and Composites
  • Dentistry(all)

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