In vivo and in vitro alterations in influenza A/H3N2 virus M2 and hemagglutinin genes: Effect of passage in MDCK-SIAT1 cells and conventional MDCK cells

Danjuan Li, Reiko Saito, Yasushi Suzuki, Isamu Sato, Hassan Zaraket, Clyde Dapat, Isolde Ma Caperig-Dapat, Hiroshi Suzuki

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

No mutations were detected in the hemagglutinin gene of influenza A/H3N2 virus isolates from patients undergoing short-term amantadine treatment. However, genetic changes occurred after serial passage in either MDCK or MDCK-SIAT1 cells. Our results showed that only a few mutations were observed in MDCK-SIAT1-passaged isolates in the presence of amantadine.

Original languageEnglish
Pages (from-to)466-468
Number of pages3
JournalJournal of Clinical Microbiology
Volume47
Issue number2
DOIs
Publication statusPublished - 2009 Feb
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)

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