In vivo analysis of hydrogen peroxide and lipid radicals in the striatum of rats under long-term administration of a neuroleptic

Hidekatsu Yokoyama, Nahoko Kasai, Yuto Ueda, Ryuji Niwa, Ryusei Konaka, Norio Mori, Nobuaki Tsuchihashi, Tomokazu Matsue, Hiroaki Ohya-Nishiguchi, Hitoshi Kamada

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

It has been hypothesized that free radicals play a causative role in tardive dyskinesia, which is an inveterate movement disorder caused by chronic administration of neuroleptics. To verify this hypothesis, rats were reared while being regularly treated with water containing a neuroleptic, haloperidol (HPD), for 1 year (HPD group). The changes in the striatal hydrogen peroxide content of the rats in the HPD and control groups were measured by using a Pt-disk microelectrode while the animals were in a freely moving state following intraperitoneal administration of HPD (HPD challenge). We also performed electron spin resonance (ESR) detection of lipid radicals in the striatum before the HPD challenge. HPD challenge led to significant elevation of the intrastriatal hydrogen peroxide in all animals, but the elevation in the HPD group was smaller than that in the control group. However, in the HPD group, marked ESR signals of intrastriatal lipid radicals were observed. We think that these results support the hypothesis on the role of free radicals in tardive dyskinesia.

Original languageEnglish
Pages (from-to)1056-1060
Number of pages5
JournalFree Radical Biology and Medicine
Volume24
Issue number6
DOIs
Publication statusPublished - 1998 Apr

Keywords

  • Electron spin resonance
  • Free radicals
  • Hydrogen peroxide
  • Lipid radical
  • Microelectrode
  • Neuroleptic
  • Striatum
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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