In vivo acceleration of ultrasonic tissue heating by microbubble agent

Shin Ichiro Umemura; Ken Ichi Kawabata; Narendra Sanghvi; Kazuaki Sasaki

In vivo acceleration of ultrasonic tissue heating by microbubble agent

Shin Ichiro Umemura, Ken Ichi Kawabata, Narendra Sanghvi, Kazuaki Sasaki

MEN - Biomedical Engineering

Research output: Contribution to journal › Conference article › peer-review

13 Citations (Scopus)

Abstract

Ultrasonic power absorbed by a microbubble was calculated through numerically solving Rayleigh-Plesset equation to analyze its nonlinear breathing motion. At an ultrasonic intensity of 0.33 W/cm²/ and a frequency of 3.2 MHz, a resonant microbubble, approximately 0.75 μm in radius, absorbed ultrasonic power of 8.6 μW. This calculation predicts that tissue ultrasonic absorption will be increased by more than twice if microbubbles are delivered to the tissue at a concentration in the order of 20 resonant microbubbles /mm³. An exteriorized murine kidney was exposed to HIFU at 3.2 MHz in degassed saline and the tissue temperature change was measured. With administration of 0.2 ml/kg Optison, the temperature elevation induced by HIFU exposure was multiplied by two to three times. This effect may have a potential use to enhance the selectivity as well as the throughput of HIFU treatments.

Original language	English
Pages (from-to)	1407-1410
Number of pages	4
Journal	Proceedings of the IEEE Ultrasonics Symposium
Volume	2
Publication status	Published - 2002 Dec 1
Event	2002 IEEE Ultrasonics Symposium - Munich, Germany Duration: 2002 Oct 8 → 2002 Oct 11

ASJC Scopus subject areas

Acoustics and Ultrasonics

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title = "In vivo acceleration of ultrasonic tissue heating by microbubble agent",

abstract = "Ultrasonic power absorbed by a microbubble was calculated through numerically solving Rayleigh-Plesset equation to analyze its nonlinear breathing motion. At an ultrasonic intensity of 0.33 W/cm2/ and a frequency of 3.2 MHz, a resonant microbubble, approximately 0.75 μm in radius, absorbed ultrasonic power of 8.6 μW. This calculation predicts that tissue ultrasonic absorption will be increased by more than twice if microbubbles are delivered to the tissue at a concentration in the order of 20 resonant microbubbles /mm3. An exteriorized murine kidney was exposed to HIFU at 3.2 MHz in degassed saline and the tissue temperature change was measured. With administration of 0.2 ml/kg Optison, the temperature elevation induced by HIFU exposure was multiplied by two to three times. This effect may have a potential use to enhance the selectivity as well as the throughput of HIFU treatments.",

author = "Umemura, {Shin Ichiro} and Kawabata, {Ken Ichi} and Narendra Sanghvi and Kazuaki Sasaki",

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T1 - In vivo acceleration of ultrasonic tissue heating by microbubble agent

AU - Umemura, Shin Ichiro

AU - Kawabata, Ken Ichi

AU - Sanghvi, Narendra

AU - Sasaki, Kazuaki

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Ultrasonic power absorbed by a microbubble was calculated through numerically solving Rayleigh-Plesset equation to analyze its nonlinear breathing motion. At an ultrasonic intensity of 0.33 W/cm2/ and a frequency of 3.2 MHz, a resonant microbubble, approximately 0.75 μm in radius, absorbed ultrasonic power of 8.6 μW. This calculation predicts that tissue ultrasonic absorption will be increased by more than twice if microbubbles are delivered to the tissue at a concentration in the order of 20 resonant microbubbles /mm3. An exteriorized murine kidney was exposed to HIFU at 3.2 MHz in degassed saline and the tissue temperature change was measured. With administration of 0.2 ml/kg Optison, the temperature elevation induced by HIFU exposure was multiplied by two to three times. This effect may have a potential use to enhance the selectivity as well as the throughput of HIFU treatments.

AB - Ultrasonic power absorbed by a microbubble was calculated through numerically solving Rayleigh-Plesset equation to analyze its nonlinear breathing motion. At an ultrasonic intensity of 0.33 W/cm2/ and a frequency of 3.2 MHz, a resonant microbubble, approximately 0.75 μm in radius, absorbed ultrasonic power of 8.6 μW. This calculation predicts that tissue ultrasonic absorption will be increased by more than twice if microbubbles are delivered to the tissue at a concentration in the order of 20 resonant microbubbles /mm3. An exteriorized murine kidney was exposed to HIFU at 3.2 MHz in degassed saline and the tissue temperature change was measured. With administration of 0.2 ml/kg Optison, the temperature elevation induced by HIFU exposure was multiplied by two to three times. This effect may have a potential use to enhance the selectivity as well as the throughput of HIFU treatments.

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