In vivo acceleration of ultrasonic tissue heating by microbubble agent

Shin Ichiro Umemura, Ken Ichi Kawabata, Narendra Sanghvi, Kazuaki Sasaki

Research output: Contribution to journalConference articlepeer-review

14 Citations (Scopus)


Ultrasonic power absorbed by a microbubble was calculated through numerically solving Rayleigh-Plesset equation to analyze its nonlinear breathing motion. At an ultrasonic intensity of 0.33 W/cm2/ and a frequency of 3.2 MHz, a resonant microbubble, approximately 0.75 μm in radius, absorbed ultrasonic power of 8.6 μW. This calculation predicts that tissue ultrasonic absorption will be increased by more than twice if microbubbles are delivered to the tissue at a concentration in the order of 20 resonant microbubbles /mm3. An exteriorized murine kidney was exposed to HIFU at 3.2 MHz in degassed saline and the tissue temperature change was measured. With administration of 0.2 ml/kg Optison, the temperature elevation induced by HIFU exposure was multiplied by two to three times. This effect may have a potential use to enhance the selectivity as well as the throughput of HIFU treatments.

Original languageEnglish
Pages (from-to)1407-1410
Number of pages4
JournalProceedings of the IEEE Ultrasonics Symposium
Publication statusPublished - 2002 Dec 1
Event2002 IEEE Ultrasonics Symposium - Munich, Germany
Duration: 2002 Oct 82002 Oct 11

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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