In vitro susceptibilites to levofloxacin and various antibacterial agents of 11,475 clinical isolates obtained from 52 centers in 2002

Keizo Yamaguchi, Akira Ohno, Fusako Kashitani, Morihiro Iwata, Makoto Kanda, Yoshiko Tsujio, Hiroya Kimoto, Hideaki Kawaguchi, Hitoshi Chiba, Koji Akizawa, Mitsuomi Kaimori, Minoru Yasujima, Tatsuro Sugiyama, Shunkoh Toyoshima, Jun Kato, Jun Okada, Yoko Tazawa, Kiyoaki Watanabe, Yoshio Kobayashi, Hiroshi UchidaShinichiro Kon, Katsuji Nakamura, Keiko Matsuda, Norihiko Shimoyama, Hidetoshi Okujima, Minoru Ito, Yosei Katayama, Kumiko Sugimoto, Hiromi Tashiro, Akira Suwabe, Ritsuko Obata, Masayuki Tsujimura, Mitsuo Kaku, Keiji Kanemitsu, Hiroyuki Kunishima, Jun Igari, Toyoko Oguri, Kyoichi Totsuka, Izumi Hayashi, Joji Shiotani, Harushige Kanno, Akira Itoh, Midori Sumitomo, Takashi Uchida, Atushi Kawabata, Chikashi Oiwa, Masamitsu Iwata, Toshinobu Horii, Shiomi Ishigo, Taira Yoshimura, Satoshi Ichiyama, Yasunao Wada, Satoshi Kimura, Shigefumi Maesaki, Kouichi Itoh, Yasunobu Noda, Takanori Yamashita, Ikuo Yamaguchi, Fumio Kageyama, Etsuko Shaku, Hisashi Baba, Kazuhisa Inuzuka, Hidetoshi Okabe, Kenichi Tatewaki, Kunihiko Moro, Masanori Aihara, Toshiharu Matsushima, Yoshihito Niki, Masao Kuw Abara, Siro Ikawa, Mobuaki Tanaka, Yasuharu Hinoda, Tetsuro Sugiura, Mikio Kamioka, Junko Ono, Tohru Takata, Hisamichi Aizawa, Junichi Honda, Zenzo Nagasawa, Yosuke Aoki, Keiichi Nakagawa, Nobuhisa Yamane, Takeshi Kageoka, Toshiharu Hongo, Junichi Masuda, Hideichi Makino, Mitsuharu Murase, Hisashi Miyamoto, Masahide Takii, Naotaka Hamazaki, Toshiharu Tsutsui, Kazufumi Hiramatsu, Tetsunori Saikawa, Tomio Kotani, Hiroaki Miyanohara

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The susceptibilities of bacteria to fluoroquinolones (FQs), especially levofloxacin, and other antimicrobial agents were investigated using 11,475 clinical isolates collected in Japan during 2002. Methicillin susceptible staphylococci, Streptococcus pyogenes, Streptococcus pneumoniae, Moraxella catarrhalis, the family of Enterobactericeae, Haemophilus influenzae and Acinetobacter spp. exhibited stable and high susceptibilities to FQs. The rate of FQs-resistant MRSA was 80-90%, being markedly higher than that of FQs-resistant MSSA. The FQs-resistance rate of MRCNS was also higher than that of MSCNS, however, it was lower than that of MRSA. No FQs-resistant clinical isolates of Salmonella spp. were detected in any of the surveys. Thirteen of Escherichai coli 696 isolates, 8 of Klebsiella pneumoniae 630 isolates and 33 of Proteus mirabilis 373 isolates produced extended-spectrum β-lactamase (ESBL), furthermore 6 of 13 in E. coli, 1 of 8 in K. pneumoniae and 14 of 31 ESBL-producing isolates, and in P. mirabilis were FQs resistant. Attention should be focused in the future on the emergence of ESBL in relation to FQs resistance. The rate of FQs-resistant P. aeruginosa isolated from urinary tract infection (UTI) was 40-60%, while 15-25% of isolates from respiratory tract infection (RTI) were resistant. IMP-1 type metallo beta-lactamase producing organisms were found in 49 of P. aeruginosa 1,095 isolates, 7 of S. marcescens 586 isolates and 4 of Acinetobacter spp. 474 isolates, respectively. Glycopeptide-resistant enterococci or S. aureus was not found.

Original languageEnglish
Pages (from-to)17-44
Number of pages28
JournalThe Japanese Journal of Antibiotics
Volume58
Issue number1
Publication statusPublished - 2005 Feb

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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