In vitro properties of Ag-containing calcium phosphates

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Infections caused by implants used for bone replacement often lead to revision surgery and delayed recovery. The use of implant materials that exhibit antibacterial activity is an effective method for decreasing the rate of such infections. Ag is widely used for fabricating implants because of its antibacterial properties. In this study, calcium phosphate powders with various Ag contents were synthesized by a precipitation method and sintered at 1373 K in air for 24 h to form compacts of biphasic hydroxyapatite (HA)/tricalcium phosphate (β-TCP) or single phase β-TCP. The in vitro dissolution test of sintered compacts was conducted in Tris-HCl solution (Tris-hydroxymethyl-aminomethane). An Escherichia coli suspension was used for the antibacterial tests. Cytotoxicity of sintered compacts toward V79 fibroblasts was evaluated. During the in vitro dissolution test of Ag-containing calcium phosphate sintered compacts, the amount of Ag ions in Tri-HCl solution initially increased and then decreased because of AgCl precipitation. The antibacterial activity of Ag-incorporated single β-TCP was clearly observed, and higher than that of the biphasic HA/β-TCP. No cytotoxicity toward V79 fibroblasts was detected for Ag-incorporated β-TCP sintered compacts.

Original languageEnglish
Title of host publicationAdvances in Ceramic Armor, Bioceramics, and Porous Materials - A Collection of Papers Presented at the 40th International Conference on Advanced Ceramics and Composites, ICACC 2016
EditorsJerry C. LaSalvia, Roger Narayan, Paolo Colombo, Paolo Colombo
PublisherAmerican Ceramic Society
Pages87-93
Number of pages7
Edition4
ISBN (Print)9781119040439
DOIs
Publication statusPublished - 2017
Event14th Armor Ceramics Symposium - 40th International Conference on Advanced Ceramics and Composites, ICACC 2016 - Daytona Beach, United States
Duration: 2016 Jan 242016 Jan 29

Publication series

NameCeramic Engineering and Science Proceedings
Number4
Volume37
ISSN (Print)0196-6219

Other

Other14th Armor Ceramics Symposium - 40th International Conference on Advanced Ceramics and Composites, ICACC 2016
CountryUnited States
CityDaytona Beach
Period16/1/2416/1/29

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

Fingerprint Dive into the research topics of 'In vitro properties of Ag-containing calcium phosphates'. Together they form a unique fingerprint.

Cite this