In vitro osteogenesis of synovium mesenchymal cells induced by controlled release of alendronate and dexamethasone from a sintered microspherical scaffold

Yingjun Wang, Xuetao Shi, Li Ren, Yongchang Yao, Dong An Wang

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    In vitro osteogenesis was successfully achieved with synovium-derived mesenchymal stem cells (SMSCs), which intrinsically have a strong chondrogenic tendency, by in situ release of alendronate (AL) and dexamethasone (Dex) from poly(lactic-co-glycolic acid) (PLGA)/hydroxyapatite (HA) sintered microspherical scaffold (PLGA/HA-SMS). Cumulative release profiles of AL and Dex from PLGA/HA-SMS and the influence on SMSCs osteogenic commitment were investigated. SMSCs seeded in Al-/Dex-loaded PLGA/HA-SMS (PLGA/HA-Com-SMS) exhibited significant osteogenic differentiation, as indicated by high yields of alkaline phosphatase (ALP) and bone calcification. In addition, mechanical properties (compressional) of PLGA/HA-Com-SMSs were also evaluated and approved. In conclusion, by promoting osteogenic commitment of SMSCs in vitro, this newly designed controlled-release system opens a new door to bone reparation and regeneration.

    Original languageEnglish
    Pages (from-to)1227-1238
    Number of pages12
    JournalJournal of Biomaterials Science, Polymer Edition
    Volume21
    Issue number8-9
    DOIs
    Publication statusPublished - 2010 May 1

    Keywords

    • ALENDRONATE
    • DEXAMETHASONE
    • HYDROXYAPATITE
    • OSTEOGENESIS
    • POLY(LACTIC-CO-GLYCOLIC ACID)
    • SCAFFOLD

    ASJC Scopus subject areas

    • Biophysics
    • Bioengineering
    • Biomaterials
    • Biomedical Engineering

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