In vitro osteogenesis of synovium mesenchymal cells induced by controlled release of alendronate and dexamethasone from a sintered microspherical scaffold

Yingjun Wang, Xuetao Shi, Li Ren, Yongchang Yao, Dong An Wang

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

In vitro osteogenesis was successfully achieved with synovium-derived mesenchymal stem cells (SMSCs), which intrinsically have a strong chondrogenic tendency, by in situ release of alendronate (AL) and dexamethasone (Dex) from poly(lactic-co-glycolic acid) (PLGA)/hydroxyapatite (HA) sintered microspherical scaffold (PLGA/HA-SMS). Cumulative release profiles of AL and Dex from PLGA/HA-SMS and the influence on SMSCs osteogenic commitment were investigated. SMSCs seeded in Al-/Dex-loaded PLGA/HA-SMS (PLGA/HA-Com-SMS) exhibited significant osteogenic differentiation, as indicated by high yields of alkaline phosphatase (ALP) and bone calcification. In addition, mechanical properties (compressional) of PLGA/HA-Com-SMSs were also evaluated and approved. In conclusion, by promoting osteogenic commitment of SMSCs in vitro, this newly designed controlled-release system opens a new door to bone reparation and regeneration.

Original languageEnglish
Pages (from-to)1227-1238
Number of pages12
JournalJournal of Biomaterials Science, Polymer Edition
Volume21
Issue number8-9
DOIs
Publication statusPublished - 2010 May 1
Externally publishedYes

Keywords

  • ALENDRONATE
  • DEXAMETHASONE
  • HYDROXYAPATITE
  • OSTEOGENESIS
  • POLY(LACTIC-CO-GLYCOLIC ACID)
  • SCAFFOLD

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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