In vitro estrogenic and antiestrogenic potential of chlorostyrenes

Seung Min Oh, Ha Ryong Kim, Kyu Hyuck Chung

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Chlorostyrenes (CSs) are primarily derived from industrial by-products and are persistent and accumulative in the environment. In this study, the estrogenic and antiestrogenic activities of CSs (o-CS, m-CS, p-CS, DiCS, octa-CS) were evaluated using in vitro bioassays. o-CS and octa-CS have both estrogenic and antiestrogenic activity in the E-SCREEN assay and the ERE-reporter gene assay, indicating effects on a classical ER-mediated pathway. m-CS showed estrogenic activity in E-SCREEN but not in ERE-reporter gene assays, indicating that it may work through a non-classical ER-mediated pathway. Finally, DiCS only showed antiestrogenic activity via an ER-independent pathway, which can be induced by depletion of endogenous E2 level by the inhibition of aromatase activity and the stimulation of E2 metabolism. Although CSs have structural similarities to dioxins/furans, they did not have AhR agonist effects. This study is the first to show the estrogenic and antiestrogenic activity of several CSs using in vitro bioassay systems, including whether the compounds work via ER-mediated or/and non-ER-mediated pathways.

Original languageEnglish
Pages (from-to)1242-1248
Number of pages7
JournalToxicology in Vitro
Volume23
Issue number7
DOIs
Publication statusPublished - 2009 Oct 1

Keywords

  • Anti-/estrogenic activity
  • Aromatase activity
  • Chlorostyrene
  • E metabolism
  • E-SCREEN assay

ASJC Scopus subject areas

  • Toxicology

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