TY - JOUR
T1 - In vitro efficacy of imipenem in combination with six antimicrobial agents against Mycobacterium abscessus
AU - Miyasaka, Tomomitsu
AU - Kunishima, Hiroyuki
AU - Komatsu, Mayumi
AU - Tamai, Kiyoko
AU - Mitsutake, Kotaro
AU - Kanemitsu, Keiji
AU - Ohisa, Yoshiharu
AU - Yanagisawa, Hideji
AU - Kaku, Mitsuo
PY - 2007/9
Y1 - 2007/9
N2 - Antimicrobial therapy of Mycobacterium abscessus infection is difficult because there are relatively few effective treatment regimens and single-agent therapy frequently fails clinically. In light of the lack of data on the susceptibility profile of M. abscessus strains recovered from infections in Japan, the in vitro activity of imipenem in combination with clarithromycin, levofloxacin, moxifloxacin, minocycline, amikacin or tobramycin was investigated by the checkerboard method and compared with the combination amikacin and cefoxitin. The combination of imipenem with moxifloxacin, levofloxacin or clarithromycin had a higher synergistic and/or additive effect than amikacin and cefoxitin. A decrease in the MIC90 value (minimum inhibitory concentration for 90% of the organisms) was observed in the presence of imipenem for clarithromycin, minocycline, levofloxacin and moxifloxacin. The data suggest that a combination regimen including imipenem may be a good choice in empirical treatment of M. abscessus infection.
AB - Antimicrobial therapy of Mycobacterium abscessus infection is difficult because there are relatively few effective treatment regimens and single-agent therapy frequently fails clinically. In light of the lack of data on the susceptibility profile of M. abscessus strains recovered from infections in Japan, the in vitro activity of imipenem in combination with clarithromycin, levofloxacin, moxifloxacin, minocycline, amikacin or tobramycin was investigated by the checkerboard method and compared with the combination amikacin and cefoxitin. The combination of imipenem with moxifloxacin, levofloxacin or clarithromycin had a higher synergistic and/or additive effect than amikacin and cefoxitin. A decrease in the MIC90 value (minimum inhibitory concentration for 90% of the organisms) was observed in the presence of imipenem for clarithromycin, minocycline, levofloxacin and moxifloxacin. The data suggest that a combination regimen including imipenem may be a good choice in empirical treatment of M. abscessus infection.
KW - Drug combination
KW - Imipenem
KW - MIC
KW - Mycobacterium abscessus
UR - http://www.scopus.com/inward/record.url?scp=34547226095&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547226095&partnerID=8YFLogxK
U2 - 10.1016/j.ijantimicag.2007.05.003
DO - 10.1016/j.ijantimicag.2007.05.003
M3 - Article
C2 - 17616451
AN - SCOPUS:34547226095
VL - 30
SP - 255
EP - 258
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
SN - 0924-8579
IS - 3
ER -
