In vitro bactericidal activity of photo-irradiated oxydol products via hydroxyl radical generation

Akira Oyamada, Hiroyo Ikai, Keisuke Nakamura, Eisei Hayashi, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The oxidative power of hydroxyl radicals has been applied to disinfection systems for the purpose of oral hygiene by utilizing blue light-induced photolysis of hydrogen peroxide (H2O2) in our laboratory. In the present study, the bactericidal potential of blue light-irradiated oxydol products via hydroxyl radical generation was compared with that of 3% (w/v) H2O2. Eleven commercially available oxydol products were used in the present study. Even though a few of the products that contained ethanol, a hydroxyl radical scavenger, as an additive showed slightly lower hydroxyl radical yield as compared with 3% (w/v) H2O2, the blue-light irradiation of each oxydol product for 3 min showed similar or superior bactericidal activity against Staphylococcus aureus to that of 3% (w/v) H2O2. The results strongly suggest that any of the oxydol products tested in the present study can be used as a source of hydroxyl radicals for the disinfection technique developed in our laboratory.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalBiocontrol Science
Issue number2
Publication statusPublished - 2013


  • Bactericidal activity
  • Hydroxyl radicaI
  • Photolyzed oxydol
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Public Health, Environmental and Occupational Health


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