In vitro apatite formation on polyamide containing carboxyl groups modified with silanol groups

Takahiro Kawai, Chikara Ohtsuki, Masanobu Kamitakahara, Kayo Hosoya, Masao Tanihara, Toshiki Miyazaki, Yoshimitsu Sakaguchi, Shigeji Konagaya

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Modification of organic polymer with silanol groups in combination with calcium salts enables the polymer to show bioactivity, that is, the polymer forms apatite on its surface after exposure to body environment. However, how modification with silanol groups influences ability of apatite formation on the polymer substrate and adhesive strength between polymer and apatite is not yet known. In the present study, polyamide containing carboxyl groups was modified with different amounts of silanol groups, and its apatite-forming ability in 1.5SBF, which contained ion concentrations 1.5 times those of simulated body fluid (SBF), was examined. The rate of apatite formation increased with increasing content of silanol groups in the polyamide films. This may be attributed to enhancement of dipole interactions. A tendency for the adhesive strength of the apatite layer on the polyamide film to be decreased with increasing content of silanol groups was observed. This may be attributed to swelling in 1.5SBF and having a high degree of shrinkage after drying. These findings clearly show that modification of organic polymers with the functional groups induces apatite deposition, and also determines the adhesive strength of the apatite layer to the organic substrates.

Original languageEnglish
Pages (from-to)1037-1042
Number of pages6
JournalJournal of Materials Science: Materials in Medicine
Volume18
Issue number6
DOIs
Publication statusPublished - 2007 Jun 1

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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